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Titolo:
Antidepressant medication use and breast cancer risk
Autore:
Cotterchio, M; Kreiger, N; Darlington, G; Steingart, A;
Indirizzi:
Canc Care Ontario, Div Prevent Oncol, Toronto, ON, Canada Canc Care Ontario Toronto ON Canada v Prevent Oncol, Toronto, ON, Canada Univ Toronto, Dept Publ Hlth Sci, Toronto, ON, Canada Univ Toronto Toronto ON Canada , Dept Publ Hlth Sci, Toronto, ON, Canada Univ Toronto, Fac Nursing, Toronto, ON, Canada Univ Toronto Toronto ON Canada Toronto, Fac Nursing, Toronto, ON, Canada Univ Toronto, Dept Psychiat, Toronto, ON, Canada Univ Toronto Toronto ON Canada ronto, Dept Psychiat, Toronto, ON, Canada
Titolo Testata:
AMERICAN JOURNAL OF EPIDEMIOLOGY
fascicolo: 10, volume: 151, anno: 2000,
pagine: 951 - 957
SICI:
0002-9262(20000515)151:10<951:AMUABC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; PROLACTIN SECRETION; UNITED-STATES; HUMAN LIVER; FLUVOXAMINE; DRUGS; CARCINOGENICITY; MOCLOBEMIDE; FLUOXETINE; ESTRADIOL;
Keywords:
antidepressive agents; breast neoplasms; case-control studies; pharmacoepidemiology; risk factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Cotterchio, M Canc Care Ontario, Div Prevent Oncol, Toronto, ON, Canada Canc Care Ontario Toronto ON Canada l, Toronto, ON, Canada
Citazione:
M. Cotterchio et al., "Antidepressant medication use and breast cancer risk", AM J EPIDEM, 151(10), 2000, pp. 951-957

Abstract

Experimental and epidemiologic studies suggest that antidepressant medication use may be associated with breast cancer risk. This hypothesis was investigated using a population-based case-control study; cases diagnosed in 1995-1996 were identified using the Ontario Cancer Registry, and controls were randomly sampled from an Ontario Ministry of Finance database. Data were collected using a self-administered questionnaire, and multivariate logistic regression was used to estimate odds ratios and 95% confidence intervals. Adjusted odds ratio estimates ranged from 0.7 to 0.8 and were not statistically significant for "ever" use of antidepressants, tricyclics, and selective serotonin reuptake inhibitors, Compared with no antidepressant use, useof tricyclic antidepressants for greater than 2 years' duration was associated with an elevated risk of breast cancer (odds ratio (OR) = 2.1, 95% confidence interval (CI): 0.9, 5.0), Of the six most commonly reported antidepressant medications, only paroxetine use was associated with an increase inbreast cancer risk (OR = 7.2, 95% CI: 0.9, 58.3), Results from this study do not support the hypothesis that "ever" use of any antidepressant medications is associated with breast cancer risk. Use of tricyclic medications for greater than 2 years, however, may be associated with a twofold elevation, and use of paroxetine may be associated with a substantial increase in breast cancer risk.

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Documento generato il 27/01/20 alle ore 02:07:42