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Titolo:
Nontraumatic osteonecrosis: MR perfusion imaging evaluation in an experimental model
Autore:
Kawamoto, S; Shirai, N; Strandberg, JD; Boxerman, JL; Bluemke, DA;
Indirizzi:
Johns Hopkins Med Inst, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD 21287 USA Johns Hopkins Med Inst Baltimore MD USA 21287 ci, Baltimore, MD 21287 USA Johns Hopkins Med Inst, Dept Comparat Med, Baltimore, MD 21287 USA Johns Hopkins Med Inst Baltimore MD USA 21287 ed, Baltimore, MD 21287 USA
Titolo Testata:
ACADEMIC RADIOLOGY
fascicolo: 2, volume: 7, anno: 2000,
pagine: 83 - 93
SICI:
1076-6332(200002)7:2<83:NOMPIE>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
AVASCULAR NECROSIS; FEMORAL-HEAD; ISCHEMIC NECROSIS; EARLY DIAGNOSIS; HISTOLOGIC CORRELATION; BONE NECROSIS; HIP; CT;
Keywords:
bones, MR; bones, necrosis; magnetic resonance (MR), perfusion study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Bluemke, DA Johns Hopkins Med Inst, Russell H Morgan Dept Radiol & Radiol Sci, 600 N Wolfe St, Baltimore, MD 21287 USA Johns Hopkins Med Inst 600 N Wolfe St Baltimore MD USA 21287 A
Citazione:
S. Kawamoto et al., "Nontraumatic osteonecrosis: MR perfusion imaging evaluation in an experimental model", ACAD RADIOL, 7(2), 2000, pp. 83-93

Abstract

Rationale and Objectives. Because the nature and time course of changes inearly, nontraumatic osteonecrosis at perfusion and magnetic resonance (MR)imaging are unknown, the authors evaluated this technique in the assessment of early osteonecrosis with a nontraumatic model. Materials and Methods. Five rabbits underwent intravenous injection of lipopolysaccharide endotoxin followed by intramuscular injection of methylprednisolone. MR imaging of the femora was performed before and at weekly intervals after endotoxin injection. Histologic findings from the areas of osteonecrosis were correlated with the findings of MR imaging and MR perfusion studies. Results. Histologic evaluation showed osteonecrosis in six femora of four animals 2-4 weeks after endotoxin injection. Findings on T1-weighted imagesof the femur were normal in all animals; T2-weighted images of one femur showed equivocal changes. On MR perfusion images, the baseline mean peak percentage of enhancement was 52.7% +/- 12.6. In the six areas without osteonecrosis, the mean percentage of enhancement was similar to the baseline percentage of enhancement at 1 week (62.2% +/- 31.2). In the four areas with diffuse osteonecrosis, there was essentially no contrast enhancement 1-4 weeks after endotoxin injection. Conclusion. T1- and T2-weighted MR imaging is insensitive to the presence of early nontraumatic osteonecrosis. MR perfusion imaging might be useful to detect early nontraumatic osteonecrosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:06:07