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Titolo:
Lyophilized platelets: continued development
Autore:
Bode, AP; Read, MS;
Indirizzi:
E Carolina Univ, Dept Pathol & Lab Med, Greenville, NC 27834 USA E Carolina Univ Greenville NC USA 27834 Lab Med, Greenville, NC 27834 USA
Titolo Testata:
TRANSFUSION SCIENCE
fascicolo: 1-2, volume: 22, anno: 2000,
pagine: 99 - 105
SICI:
0955-3886(200002/04)22:1-2<99:LPCD>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRESERVATION; TRANSFUSION;
Keywords:
blood platelets; lyophilization; transfusion; hemostasis; adhesion; surface glycoproteins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Bode, AP E Carolina Univ, Dept Pathol & Lab Med, Greenville, NC 27834 USA E Carolina Univ Greenville NC USA 27834 Greenville, NC 27834 USA
Citazione:
A.P. Bode e M.S. Read, "Lyophilized platelets: continued development", TRANSFUS SC, 22(1-2), 2000, pp. 99-105

Abstract

In our initial investigation of functionality of platelets freeze-dried after stabilization with 1.8% paraformaldehyde, we found that the rehydrated cells were morphologically intact and retained adhesive and procoagulant properties. Further testing of fixed, washed freeze-dried platelets has demonstrated the physiologic nature of their adhesion in vitro and their hemostatic efficacy in vivo in correcting the bleeding time in thrombocytopenic animal models. Binding studies with monoclonal antibodies and radiolabelled ligands indicate an intact GpIb vonWillebrands factor receptor as on fresh platelets, but a somewhat attenuated GpIIbIIIa fibrinogen receptor. Repeatedinfusion of canine lyophilized platelet preparations in a single recipientover several months has shown no incipient cytopenia upon infusion of new doses nor accelerated clearance of platelets. These findings suggest minimal risk of systemic thrombosis or severe immunogenic reaction and support the notion of approaching clinical trials as soon as possible. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:40:15