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Titolo:
Changes in adrenocortical function with aging and therapeutic implications
Autore:
Harper, AJ; Buster, JE; Casson, PR;
Indirizzi:
Baylor Coll Med, Dept Obstet & Gynecol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 tet & Gynecol, Houston, TX 77030 USA
Titolo Testata:
SEMINARS IN REPRODUCTIVE ENDOCRINOLOGY
fascicolo: 4, volume: 17, anno: 1999,
pagine: 327 - 338
SICI:
0734-8630(1999)17:4<327:CIAFWA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SULFATE DHEAS LEVELS; DEHYDROEPIANDROSTERONE-SULFATE; POSTMENOPAUSAL WOMEN; CARDIOVASCULAR-DISEASE; ADRENAL-CORTEX; 3-BETA-HYDROXYSTEROID DEHYDROGENASE; PLASMA DEHYDROEPIANDROSTERONE; ORAL DEHYDROEPIANDROSTERONE; INSULIN SENSITIVITY; DENSITY-LIPOPROTEIN;
Keywords:
dehydroepiandrosterone; dehydroepiandrosterone sulfate; androgens; adrenal cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
86
Recensione:
Indirizzi per estratti:
Indirizzo: Casson, PR Ottawa Civic Hosp, Div Reprod Med, Dept Obstet & Gynaecol, 737 Parkdale,Suite 537, Ottawa, ON K1Y 4E9, Canada Ottawa Civic Hosp 737 Parkdale,Suite 537 Ottawa ON Canada K1Y 4E9
Citazione:
A.J. Harper et al., "Changes in adrenocortical function with aging and therapeutic implications", SEM REP END, 17(4), 1999, pp. 327-338

Abstract

Throughout life, the adrenal cortex exhibits dramatic morphogenic and steroidogenic changes. While there is subtle senescent decline in aldosterone, and a similarly subtle increase in cortisol, the adrenal androgens dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) decline with age in a situation similar to menopause, and this decline is considered by some to aggravate some age-related diseases. This decline is associated with an almost complete loss of the inner zone of the adrenal cortex, knownas the zona reticularis. This review addresses these adrenal cortical changes, and explores their clinical significance. In particular, the clinical data on DHEA replacement in aging is addressed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:43:17