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Titolo:
Role of dopamine in prepulse inhibition of acoustic startle
Autore:
Zhang, JH; Forkstam, C; Engel, JA; Svensson, L;
Indirizzi:
Gothenburg Univ, Dept Pharmacol, S-40530 Gothenburg, Sweden Gothenburg Univ Gothenburg Sweden S-40530 ol, S-40530 Gothenburg, Sweden
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 149, anno: 2000,
pagine: 181 - 188
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED DEFICIT SYNDROME; EXTRACELLULAR DOPAMINE; INVIVO MICRODIALYSIS; NUCLEUS-ACCUMBENS; RAT STRIATUM; IN-VIVO; AMPHETAMINE; SCHIZOPHRENIA; CLOZAPINE; HALOPERIDOL;
Keywords:
acoustic startle response; prepulse inhibition; sensorimotor gating; schizophrenia; dopamine; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Svensson, L Gothenburg Univ, Dept Pharmacol, POB 431, S-40530 Gothenburg, Sweden Gothenburg Univ POB 431 Gothenburg Sweden S-40530 urg, Sweden
Citazione:
J.H. Zhang et al., "Role of dopamine in prepulse inhibition of acoustic startle", PSYCHOPHAR, 149(2), 2000, pp. 181-188

Abstract

Rationale: Prepulse inhibition of acoustic startle is the reduction in startle response to an intense auditory stimulus when this stimulus is immediately preceded by a weaker prestimulus. Prepulse inhibition occurs normally in humans and experimental animals, but schizophrenic persons often exhibita marked impairment in this measure. Previous studies have shown that dopamine (DA)-dependent neuronal mechanisms are involved in the modulation of prepulse inhibition. Objective: Experiments were conducted in rats to elucidate further the involvement of DA-ergic mechanisms in prepulse inhibition. Results: In line with previous studies, the indirect DA agonist, amphetamine, was shown to decrease prepulse inhibition. A close reverse relationship over time between DA overflow in the nucleus accumbens and prepulse inhibition was obtained using a technique allowing concomitant measurement of these parameters in awake, freely moving rats. This effect was more pronounced in amphetamine-treated rats compared to rats treated with equimolar doses of cocaine, which increased DA overflow without affecting prepulse inhibition. In other experiments, the combined treatment with subthreshold doses of the selective DA D-1 agonist, SKF 38393, and the selective DA D-2 agonist, quinpirole, was also shown to decrease prepulse inhibition. Finally, the selective DA D-2 antagonist, raclopride, was shown to enhance prepulse inhibition. Conclusions: In line with previous studies, it is concluded that DA neurotransmission is involved in the modulation of prepulse inhibition and that the ventral part of the mesostriatal DA system may serve an important role in this modulation. Furthermore, the possibility is discussed that the discrepant results on prepulse inhibition obtained with amphetamine and cocaine may disclose functionally relevant differences in their mechanisms of action, and that the enhancement of prepulse inhibition induced by some anti-psychotics in rats may reflect their propensity to induce adverse mental effects in humans.

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Documento generato il 05/04/20 alle ore 07:16:18