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Titolo:
Impulsiveness and the prolactin response to d-fenfluramine
Autore:
Evans, J; Platts, H; Lightman, S; Nutt, D;
Indirizzi:
Univ Bristol, Div Psychiat, Bristol BS2 8DZ, Avon, England Univ Bristol Bristol Avon England BS2 8DZ Bristol BS2 8DZ, Avon, England Bristol Royal Infirm, Div Med, Bristol BS2 8HW, Avon, England Bristol Royal Infirm Bristol Avon England BS2 8HW BS2 8HW, Avon, England
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 149, anno: 2000,
pagine: 147 - 152
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN TRANSPORTER GENE; HUMAN PERSONALITY-TRAIT; RECEPTOR D4DR; POLYMORPHISM; ASSOCIATION; BEHAVIOR; DORSAL;
Keywords:
impulsiveness; personality; serotonin; d-fenfluramine; prolactin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Evans, J Univ Bristol, Div Psychiat, 41 St Michaels Hill, Bristol BS2 8DZ,Avon, England Univ Bristol 41 St Michaels Hill Bristol Avon England BS2 8DZ and
Citazione:
J. Evans et al., "Impulsiveness and the prolactin response to d-fenfluramine", PSYCHOPHAR, 149(2), 2000, pp. 147-152

Abstract

Rationale: A number of studies have reported abnormalities of serotonin function in aggressive and impulsive behaviours in psychiatric and forensic populations. It is unknown whether this is because serotonin function plays a part in determining the dimension of trait impulsiveness in the general population or whether this is restricted to these behaviourally extreme groups. Method: The prolactin response to d-fenfluramine was measured in subjects scoring high and low on a scale of impulsiveness selected from a panel of healthy volunteers screened for impulsiveness. Measures included the 17 impulsiveness scale, State Trait Anger Expression Inventory (STAngXI) and the Tridimensional Personality Questionnaire (TPQ). Plasma cortisol was also determined along with fenfluramine and its metabolite norfenfluramine. Results: The high impulsive group had reduced AUC (PRL) compared with the low impulsive group; this remained significant after adjusting for baseline prolactin, cortisol and drug levels. There was no significant association between impulsiveness, the harm avoidance subscale of the TPQ or trait anger (STAngXI) and prolactin rise. Repeated serum prolactin measures were not significantly different between the two groups. Conclusions: This study providessome support to the hypothesis that reduced serotonin function contributesto high trait impulsiveness and is not restricted to behaviourally extremepopulations.

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Documento generato il 01/04/20 alle ore 17:38:49