Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Transplantation into genetically alymphoid mice as an approach to dissect the roles of uterine natural killer cells during pregnancy - A review
Autore:
Croy, BA; Di Santo, JP; Greenwood, JD; Chantakru, S; Ashkar, AAA;
Indirizzi:
Univ Guelph, Dept Biomed Sci, Guelph, ON N1G 2W1, Canada Univ Guelph Guelph ON Canada N1G 2W1 omed Sci, Guelph, ON N1G 2W1, Canada Inst Pasteur, Dept Immunol, INSERM, U429, F-75724 Paris, France Inst Pasteur Paris France F-75724 l, INSERM, U429, F-75724 Paris, France
Titolo Testata:
PLACENTA
, volume: 21, anno: 2000, supplemento:, A
pagine: S77 - S80
SICI:
0143-4004(200003/04)21:<S77:TIGAMA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
METRIAL GLAND-CELLS; MURINE PREGNANCY; MOUSE UTERUS; BONE-MARROW; GAMMA; LOCALIZATION; EXPRESSION; CYTOKINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Croy, BA Univ Guelph, Dept Biomed Sci, Guelph, ON N1G 2W1, Canada Univ Guelph Guelph ON Canada N1G 2W1 Guelph, ON N1G 2W1, Canada
Citazione:
B.A. Croy et al., "Transplantation into genetically alymphoid mice as an approach to dissect the roles of uterine natural killer cells during pregnancy - A review", PLACENTA, 21, 2000, pp. S77-S80

Abstract

Mice genetically deficient in the natural killer (NK) cell lineage lack uterine (uNK cells) and demonstrate morphometrically-quantifiable histopathology within their implantation sites. Two particular mouse strains, tg epsilon,26 and RAG-2 null x gamma c null, have been used successfully as transplant recipients to address questions relating to the biology of uNK cells. uNK cells did not differentiate within decidualized uterine graft segments from normal mice, which were anastomosed orthotopically into immunodeficienthosts. uNK cells did appear in similar grafts placed into immunocompetent hosts, indicating that uNK cells or their progenitors must home to the uterus. This was confirmed by splenocyte transplantation into pregnant uNK celldeficient recipients. Only splenocytes from pregnant donors, not those from non-pregnant donors, homed to the uterus. Homing in this in vivo assay was independent of the CC-chemokine receptors, CCR-2 and CCR-5. Longer-term bone marrow cell reconstitution of neonatal or virgin adult uNK cell-deficient mice has identified a functional role for uNK cells in modification of the decidual arterioles which is mediated by IFN-gamma. By utilizing mutant and gene-ablated mice as donors for tissue or haematopoietic cell transplants to uNK cell deficient mice, it should be possible to fully characterize the in vivo regulation and functions of these pregnancy-specific uterine lymphocytes. (C) 2000 IFPA and Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 22:04:33