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Titolo:
Immunohistochemical detection of cytokeratin and epithelial membrane antigen in leiomyosarcoma: A systematic study of 100 cases
Autore:
Iwata, J; Fletcher, CDM;
Indirizzi:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Pathol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Pathol, Boston, MA 02115 USA Kochi Med Sch, Dept Pathol, Kochi, Japan Kochi Med Sch Kochi JapanKochi Med Sch, Dept Pathol, Kochi, Japan
Titolo Testata:
PATHOLOGY INTERNATIONAL
fascicolo: 1, volume: 50, anno: 2000,
pagine: 7 - 14
SICI:
1320-5463(200001)50:1<7:IDOCAE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; DEEP SOFT-TISSUE; CLINICOPATHOLOGICAL ANALYSIS; CUTANEOUS LEIOMYOSARCOMA; MONOCLONAL-ANTIBODIES; NONEPITHELIAL TISSUES; CULTURED-CELLS; HUMAN ARTERIES; TUMORS; EXPRESSION;
Keywords:
cytokeratin; epithelial membrane antigen; immunohistochemistry; leiomyosarcoma; smooth muscle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Fletcher, CDM Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Pathol, 75 Francis St, Boston, MA 02115 USA Harvard Univ 75 Francis St Boston MA USA02115 MA 02115 USA
Citazione:
J. Iwata e C.D.M. Fletcher, "Immunohistochemical detection of cytokeratin and epithelial membrane antigen in leiomyosarcoma: A systematic study of 100 cases", PATHOL INT, 50(1), 2000, pp. 7-14

Abstract

Although 'aberrant' expression of the epithelial markers, cytokeratin (CK)and epithelial membrane antigen (EMA), in leiomyosarcoma has been described previously, there has not been a study of this phenomenon with clinicopathological correlation in a large series of lesions at different anatomical sites. We investigated systematically the immunohistochemical reactivity for CK and EMA in 100 cases of leiomyosarcoma. CK and EMA were positive in 38% and 44% of the cases, respectively. Although staining was usually focal, extensive immunoreactivity was observed in 11% with CK and 6% with EMA. There was no correlation between immunoreactivity for CK and EMA in leiomyosarcomas and non-neoplastic smooth muscle at the same location. Immunoreactivity for CK and EMA was not correlated with the location, age, sex, histological grade, or histological features, except for more frequent EMA positivity in vascular and uterine tumors than in soft tissue cases. These results indicate that CK and/or EMA-positive leiomyosarcomas do not have distinctiveclinicopathological features differing from those of negative cases. However, the considerable frequency of immunoreactivity for these epithelial markers in leiomyosarcoma, occasionally with diffuse and strong immunopositivity, should be recognized as a potentially serious diagnostic pitfall in thedifferential diagnosis of other malignant spindle cell neoplasms.

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Documento generato il 01/12/20 alle ore 22:52:28