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Titolo:
Intrathecally administered spermine produces the scratching, biting and licking behaviour in mice
Autore:
Tan-No, K; Taira, A; Wako, K; Niijima, F; Nakagawasai, O; Tadano, T; Sakurada, C; Sakurada, T; Kisara, K;
Indirizzi:
Tohoku Pharmaceut Univ, Dept Pharmacol, Aoba Ku, Sendai, Miyagi 9818558, Japan Tohoku Pharmaceut Univ Sendai Miyagi Japan 9818558 Miyagi 9818558, Japan Daiichi Coll Pharmaceut Sci, Dept Biochem, Minami Ku, Fukuoka 8158511, Japan Daiichi Coll Pharmaceut Sci Fukuoka Japan 8158511 Fukuoka 8158511, Japan
Titolo Testata:
PAIN
fascicolo: 1-2, volume: 86, anno: 2000,
pagine: 55 - 61
SICI:
0304-3959(200005)86:1-2<55:IASPTS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; SUBSTANCE-P ANALOGS; INDUCED AVERSIVE BEHAVIOR; NK1 RECEPTOR ANTAGONIST; AMINO-ACID RECEPTORS; FREELY MOVING RATS; MOUSE SPINAL-CORD; DORSAL HORN; PHARMACOLOGICAL CHARACTERIZATION; NEUROKININ-1 RECEPTOR;
Keywords:
spermine; ifenprodil; NMDA antagonist; NK-1 receptor antagonist; intrathecal administration; scratching/biting/licking behaviour; mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Tan-No, K Tohoku Pharmaceut Univ, Dept Pharmacol, Aoba Ku, 4-4-1 Komatsushima, Sendai, Miyagi 9818558, Japan Tohoku Pharmaceut Univ 4-4-1 Komatsushima Sendai Miyagi Japan 9818558
Citazione:
K. Tan-No et al., "Intrathecally administered spermine produces the scratching, biting and licking behaviour in mice", PAIN, 86(1-2), 2000, pp. 55-61

Abstract

Intrathecal (i.t.) administration of spermine (0.1-10000 fmol), an endogenous polyamine, produced the behavioural response mainly consisting of biting and/or licking of the hindpaw along with a slight hindlimb scratching directed toward the flank in mice, which peaked at 5-15 min and almost disappeared at 30 min after an injection. The behaviour induced by spermine (10 pmol) was dose-dependently inhibited by intraperitoneal injection of morphine(0.125-0.5 mg/kg). The characteristic behaviour was also inhibited dose-dependently by i.t, coadministration of ifenprodil (62.5-4000 pmol), a competitive antagonist of the polyamine recognition site on N-methyl-D-aspartate (NMDA) receptor ion-channel complex, and D(-)-2-amino-5-phosphonovaleric acid (D-APV) (0.5-2 nmol) and 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) (7.8-500 pmol), the competitive NMDA receptor antagonists, and (5R,10S)-(+)-5-methyl-10,11 -dihydro-5H-dibenzo[a,b]cycloheptene-5, 10-imine hydrogen maleate (MK-801) (0.5-4 nmol), an NMDA ion-channel blocker, but not by 6-cyano-7- nitroquinoxaline-2,3-dione (CNQX), a non-NMDA receptor antagonist. Both (2S,3S)-[cis-2-(diphenylmethyl)-N-[(2-methoxypheny])-1-azabicyclo[2.2.2]octane-3-amine] (CP-96,345), a non-peptidic neurokinin-1 (NK-1) receptor antagonist, and CP-96,344, its inactive 2R,3R enantiomer, inhibited spermine-induced behavioural response in a dose-dependent manner. However, [Tyr(6), D-Phe(7), D-His(9)]-substance P(6-11) (sendide) and [D-Phe(7), D-His(9)]-substance P(6-11), the selective antagonists for NK-1 receptors, were without affecting spermine-induced behaviour. These results indicate that spermine-induced behaviour is mediated through the polyamine recognition site on NMDA receptor ion-channel complex without the involvement of substance P system in the mouse spinal cord. (C) 2000 international Association for the Study of Pain. Published by Elsevier Science B.V. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:10:59