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Titolo:
Highly stereoselective synthesis and biological properties of nucleoside analogues bearing a spiro inserted oxirane ring
Autore:
Tronchet, JMJ; Kovacs, I; Seman, M; Dilda, P; De Clercq, E; Balzarini, J;
Indirizzi:
Univ Geneva, Dept Organ Pharmaceut Chem, CH-1211 Geneva 4, Switzerland Univ Geneva Geneva Switzerland 4 eut Chem, CH-1211 Geneva 4, Switzerland Labs Mayoly Spindler, Dept Res, F-78401 Chatou, France Labs Mayoly Spindler Chatou France F-78401 t Res, F-78401 Chatou, France Catholic Univ Louvain, Rega Inst Med Res, B-3000 Louvain, Belgium CatholicUniv Louvain Louvain Belgium B-3000 es, B-3000 Louvain, Belgium
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 4, volume: 19, anno: 2000,
pagine: 775 - 794
SICI:
1525-7770(2000)19:4<775:HSSABP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
REVERSE-TRANSCRIPTASE; INHIBITORS; SPIRONUCLEOSIDES; SENSITIVITY; DERIVATIVES; STRAINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Tronchet, JMJ Univ Geneva, Dept Organ Pharmaceut Chem, CH-1211 Geneva 4, Switzerland Univ Geneva Geneva Switzerland 4 211 Geneva 4, Switzerland
Citazione:
J.M.J. Tronchet et al., "Highly stereoselective synthesis and biological properties of nucleoside analogues bearing a spiro inserted oxirane ring", NUCLEOS NUC, 19(4), 2000, pp. 775-794

Abstract

Starting from 2',5'-di-O-TBDMS-3'-ketouridine 1 or its thymine analogue 2,both xylo (3-10) and ribo (20) epimers of a series of 3"-substituted 3'-spironucleosides have been obtained in good yields and with a total stereoselectivity. Most new compounds were moderately cytotoxic with in some cases slightly selective antiproliferative activities. None of these compounds wasactive against HIV, but some other antiviral activities against HSV-2, CMV, EBV, or VZV, in the micromolar range, were noted in specific cases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:37:04