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Titolo:
Cerebrospinal beta-amyloid ((1-42)) in early Alzheimer's disease: association with apolipoprotein E genotype and cognitive decline
Autore:
Riemenschneider, M; Schmolke, M; Lautenschlager, N; Guder, WG; Vanderstichele, H; Vanmechelen, E; Kurz, A;
Indirizzi:
Tech Univ Munich, Dept Psychiat & Psychotherapy, D-81675 Munich, Germany Tech Univ Munich Munich Germany D-81675 therapy, D-81675 Munich, Germany Stadt Krankenhaus Munchen Bogenhausen, Inst Klin Chem, D-8000 Munich, Germany Stadt Krankenhaus Munchen Bogenhausen Munich Germany D-8000 ich, Germany Innogenet, Ghent, Belgium Innogenet Ghent BelgiumInnogenet, Ghent, Belgium
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1-2, volume: 284, anno: 2000,
pagine: 85 - 88
SICI:
0304-3940(20000421)284:1-2<85:CB(IEA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIAGNOSTIC-CRITERIA; CLINICAL-DIAGNOSIS; FLUID TAU; BETA-AMYLOID((1-42)); A-BETA-42; CSF;
Keywords:
biomarker; Alzheimer's disease; beta-amyloid; cerebrospinal fluid; ApoE genotype;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Riemenschneider, M Tech Univ Munich, Dept Psychiat & Psychotherapy, Ismaningerstr 22, D-81675Munich, Germany Tech Univ Munich Ismaningerstr 22 Munich Germany D-81675
Citazione:
M. Riemenschneider et al., "Cerebrospinal beta-amyloid ((1-42)) in early Alzheimer's disease: association with apolipoprotein E genotype and cognitive decline", NEUROSCI L, 284(1-2), 2000, pp. 85-88

Abstract

The concentration of beta-Amyloid((1-42)) protein (A beta 42) in cerebrospinal fluid (CSF) was determined in 75 Alzheimer's disease (AD) patients, 35patients with other causes of dementia and 30 cognitively healthy age-matched controls. A significant decrease of A beta 42 concentration was found in AD patients, even in 25 subjects with very mild dementia as compared to patients with other causes of dementia and controls. Within AD patients we observed a significant decline of A beta 42 from very mild to mild and moderate dementia. In addition, A beta 42 levels were negatively correlated withthe severity of cognitive impairment and with the number of epsilon 4 alleles inherited. We conclude that measurement of A beta 42 in CSF might be helpful for identifying AD at an early stage and also for tracking the clinical course. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 08:43:16