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Titolo:
An examination of glutamate decarboxylase(65) immunoreactive puncta with respect to rat ventral pallidum neurons after repeated cocaine administration
Autore:
De Leon, KR; Todtenkopf, MS; Stellar, JR;
Indirizzi:
Northeastern Univ, Dept Psychol, Boston, MA 02115 USA Northeastern Univ Boston MA USA 02115 Dept Psychol, Boston, MA 02115 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1-2, volume: 284, anno: 2000,
pagine: 69 - 72
SICI:
0304-3940(20000421)284:1-2<69:AEOGDI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; NUCLEUS-ACCUMBENS; BEHAVIORAL SENSITIZATION; MICROINJECTIONS; STIMULATION; EXPRESSION; REWARD;
Keywords:
cocaine; behavioral sensitization; glutamate decarboxylase; ventral pallidum; nucleus accumbens; immunocytochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: De Leon, KR Northeastern Univ, Dept Psychol, 360 Huntington Ave,125 NI, Boston, MA 02115 USA Northeastern Univ 360 Huntington Ave,125 NI Boston MA USA 02115
Citazione:
K.R. De Leon et al., "An examination of glutamate decarboxylase(65) immunoreactive puncta with respect to rat ventral pallidum neurons after repeated cocaine administration", NEUROSCI L, 284(1-2), 2000, pp. 69-72

Abstract

The ventral pallidum is known to have topographically organized reciprocalgamma-aminobutyric acid-ergic projections with the nucleus accumbens, and changes in these connections may play a role in mediating the behavioral sensitizing effect of repeated exposure to cocaine. The present study investigated glutamate decarboxylase-65 (GAD(65)) immunoreactivity in the rat ventra I pallidum after repeated cocaine administration. Male Sprague-Dawley rats were administered bi-daily injections of 15 mg/kg cocaine or saline vehicle for 5 consecutive days. After 2 or 14 days of withdrawal, ventral pallidal sections were immunocytochemically processed for GAD(65) immunoreactivepuncta and counts were made. in both groups, there were no statistically significant differences in the number or density of GAD(65) puncta in medialor lateral portions either in contact with neuronal cell bodies or in the neuropil after 2 or 14 days of withdrawal. The results suggest that there is no alteration in the number of GABAergic boutons expressing GAD(65) immunoreactivity in the ventral pallidum after repeated exposure to cocaine. (C)2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:06:53