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Titolo:
Neurons containing Alz-50-immunoreactive granules around the cerebral infarction: evidence for the lysosomal degradation of altered tau in human brain?
Autore:
Ikeda, K; Akiyama, H; Arai, T; Kondo, H; Haga, C; Tsuchiya, K; Yamada, S; Murayama, S; Hori, A;
Indirizzi:
Tokyo Inst Psychiat, Dept Neuropathol, Setagaya Ku, Tokyo 1568585, Japan Tokyo Inst Psychiat Tokyo Japan 1568585 etagaya Ku, Tokyo 1568585, Japan Tokyo Metropolitan Matsuzawa Hosp, Setagaya Ku, Tokyo 1560057, Japan TokyoMetropolitan Matsuzawa Hosp Tokyo Japan 1560057 kyo 1560057, Japan Tokyo Inst Gerontol, Dept Neuropathol, Itabashi Ku, Tokyo 1730015, Japan Tokyo Inst Gerontol Tokyo Japan 1730015 tabashi Ku, Tokyo 1730015, Japan Hannover Med Coll, Inst Neuropathol, D-30625 Hannover, Germany Hannover Med Coll Hannover Germany D-30625 ol, D-30625 Hannover, Germany
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 284, anno: 2000,
pagine: 187 - 189
SICI:
0304-3940(20000428)284:3<187:NCAGAT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIA; ALZ-50;
Keywords:
lysosomes; tau; Alz-50; infarction; ischemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Ikeda, K Tokyo Inst Psychiat, Dept Neuropathol, Setagaya Ku, 2-1-8 Kamikitazawa, Tokyo 1568585, Japan Tokyo Inst Psychiat 2-1-8 Kamikitazawa Tokyo Japan 1568585 Japan
Citazione:
K. Ikeda et al., "Neurons containing Alz-50-immunoreactive granules around the cerebral infarction: evidence for the lysosomal degradation of altered tau in human brain?", NEUROSCI L, 284(3), 2000, pp. 187-189

Abstract

Little is known about the metabolic process of tau and tau-derived substances. Alz-50- and tau 2-immunoreactivities in intracellular granules of neurons were observed in regions surrounding infarcted foci in the human cerebral cortex. Ultrastructurally, these granules in the fresh infarcted region exhibited primary lysosome-like structures, while those in old infarctions were lipofuscin. These findings indicate that tau is metabolized within lysosomes in neurons damaged by ischemic injury in human cortical penumbra. Alz-50-positive granules were more prominent in fresh infarction than in old infarction. After undergoing degradation and modification, altered tau might remain, at least partially, in secondary lysosomes. (C) 2000 Elsevier Science Ireland Ltd. Ail rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:32:25