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Titolo:
Lack of temperature-induced polypnea in histamine H1 receptor-deficient mice
Autore:
Izumizaki, M; Iwase, M; Kimura, H; Yanai, K; Watanabe, T; Watanabe, T; Homma, I;
Indirizzi:
Showa Univ, Sch Med, Dept Physiol, Shinagawa Ku, Tokyo 1428555, Japan Showa Univ Tokyo Japan 1428555 ysiol, Shinagawa Ku, Tokyo 1428555, Japan Tohoku Univ, Sch Med, Dept Pharmacol, Aoba Ku, Sendai, Miyagi 9808575, Japan Tohoku Univ Sendai Miyagi Japan 9808575 Ku, Sendai, Miyagi 9808575, Japan Kyushu Univ, Med Inst Bioregulat, Dept Mol Immunol, Fukuoka 8128582, JapanKyushu Univ Fukuoka Japan 8128582 pt Mol Immunol, Fukuoka 8128582, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 284, anno: 2000,
pagine: 139 - 142
SICI:
0304-3940(20000428)284:3<139:LOTPIH>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
RABBIT TRACHEAL TENSION; RAT-BRAIN; NEURONS; INVOLVEMENT; BEHAVIOR; FIBERS; NERVE;
Keywords:
histamine H1 receptors; body temperature; breathing pattern; carbon dioxide; heat loss; expiratory time;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Homma, I Showa Univ, Sch Med, Dept Physiol, Shinagawa Ku, 1-5-8 Hatanodai,Tokyo 1428555, Japan Showa Univ 1-5-8 Hatanodai Tokyo Japan 1428555 yo 1428555, Japan
Citazione:
M. Izumizaki et al., "Lack of temperature-induced polypnea in histamine H1 receptor-deficient mice", NEUROSCI L, 284(3), 2000, pp. 139-142

Abstract

Breathing patterns are influenced by body temperature. However, the central mechanism for changes of breathing patterns is unknown. We previously showed that central histamine contributed to temperature-induced polypnea in mice (Izumizaki, M., Iwase, M., Homma, I., Yanai, K., Watanabe, T. and Watanabe, T., Central histamine contributed to the temperature-induced polypnea in mice, Neurosci. Res., 23 (1999) S282). In this study we examined the role of central histamine H1 receptors in temperature-induced polypnea using wild and mutant mice lacking histamine H1 receptors. Breathing patterns werecharacterized at two different body temperatures during hypercapnia under conscious conditions. in wild mice a raised body temperature increased respiratory frequency mainly due to a reduction in expiratory time, whereas in mutant mice respiratory frequency did not increase even though the body temperature was elevated. These results indicate that central histamine contributes to an increase in respiratory frequency due to a reduction in expiratory time through histamine H1 receptors when body temperature is raised. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:21:57