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Titolo:
The neuropsychology of preclinical Alzheimer's disease and mild cognitive impairment
Autore:
Collie, A; Maruff, P;
Indirizzi:
Mental Hlth Res Inst, Neurophysiol & Neurovisual Res Unit, Parkville, Vic 3052, Australia Mental Hlth Res Inst Parkville Vic Australia 3052 le, Vic 3052, Australia La Trobe Univ, Sch Psychol Sci, Bundoora, Vic, Australia La Trobe Univ Bundoora Vic Australia ychol Sci, Bundoora, Vic, Australia
Titolo Testata:
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
fascicolo: 3, volume: 24, anno: 2000,
pagine: 365 - 374
SICI:
0149-7634(200005)24:3<365:TNOPAD>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
E EPSILON-4 ALLELE; SUBJECTIVE MEMORY COMPLAINTS; HEALTHY ELDERLY PERSONS; DEPRESSIVE SYMPTOMS; HIPPOCAMPAL-FORMATION; UNIPOLAR DEPRESSION; PRESENILIN-1 GENE; TEMPORAL LOBES; DEMENTIA; AGE;
Keywords:
preclinical; Alzheimer's disease; neuropsychology; mild cognitive impairment; hippocampus; memory; medial temporal lobes;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
96
Recensione:
Indirizzi per estratti:
Indirizzo: Collie, A Mental Hlth Res Inst, Neurophysiol & Neurovisual Res Unit, Parkville, Vic 3052, Australia Mental Hlth Res Inst Parkville Vic Australia 3052 52, Australia
Citazione:
A. Collie e P. Maruff, "The neuropsychology of preclinical Alzheimer's disease and mild cognitive impairment", NEUROSCI B, 24(3), 2000, pp. 365-374

Abstract

Subjects in the preclinical stages of Alzheimer's disease (AD) typically record neuropsychological performance between that of healthy older individuals and demented patients. More specifically, deficits on measures of verbal episodic memory are commonly reported in these patients, while other cognitive functions (e.g. language, praxis and executive function) seem to be spared. A similar neuropsychological profile is observed in elderly subjectswith mild cognitive impairment (MCI), a disorder that is attracting increasing research interest. Evidence from lesion and functional imaging studies, as well as volumetric imaging in probable AD and MCI patients, suggests that the cognitive deficits observed in these disorders may be related to medial temporal lobe dysfunction. An issue currently under investigation is whether MCI represents the preclinical stages of AD or a distinct and staticcognitive aetiology. In an attempt to address this issue, present investigations are adopting a convergent approach to the detection of preclinical AD, where multiple risk factors are considered when making a diagnosis. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 18:34:39