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Titolo:
Animal models of acute drug-induced akathisia - a review
Autore:
Sachdev, PS; Brune, M;
Indirizzi:
Prince Wales Hosp, Inst Neuropsychiat, Randwick, NSW 2031, Australia Prince Wales Hosp Randwick NSW Australia 2031 ndwick, NSW 2031, Australia Univ New S Wales, Sch Psychiat, Sydney, NSW, Australia Univ New S Wales Sydney NSW Australia h Psychiat, Sydney, NSW, Australia Ruhr Univ Bochum, Dept Psychiat & Psychotherapy, D-4630 Bochum, Germany Ruhr Univ Bochum Bochum Germany D-4630 hotherapy, D-4630 Bochum, Germany
Titolo Testata:
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
fascicolo: 3, volume: 24, anno: 2000,
pagine: 269 - 277
SICI:
0149-7634(200005)24:3<269:AMOADA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLEPTIC-INDUCED AKATHISIA; TARDIVE-DYSKINESIA; PSYCHOTROPIC-DRUGS; RAT; DOPAMINE; HALOPERIDOL; ANTAGONISTS; PRIMATES; 5-HYDROXYTRYPTAMINE; FLUOXETINE;
Keywords:
akathisia; antipsychotic drugs; dopamine; serotonin; animals; non-human primates; selective serotonin reuptake inhibitors;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Sachdev, PS Prince Wales Hosp, Inst Neuropsychiat, Randwick, NSW 2031, Australia Prince Wales Hosp Randwick NSW Australia 2031 2031, Australia
Citazione:
P.S. Sachdev e M. Brune, "Animal models of acute drug-induced akathisia - a review", NEUROSCI B, 24(3), 2000, pp. 269-277

Abstract

Akathisia is a complex neurobehavioural side effect of neuroleptics and some other drugs which is characterised by subjective report and objective manifestations of restlessness. Its pathophysiology is poorly understood and there are many limitations to its investigation in humans. This paper reviews the various attempts that have been made in modelling acute akathisia inanimals. Homologous as well as isomorphic models have been attempted, but most models are partial as they reproduce either the subjective or the objective features of the syndrome. None of the available models has bren fullyvalidated. Neuroleptic-induced defecation in the rat, even though constrained by a lack of symptom similarity and thereby face validity, has been most studied as a model of subjective akathisia. Rat models of restlessness, in particular those involving the use of serotonergic drugs or lesions of the veneral tegmentum or medial prefrontal cortex, are interesting partial models that should be further investigated. Neuroleptic-induced akathisia is observed in primates and has been modelled in dogs, and these should be studied further for their validation. It is also necessary to consider the subtypes of akathisia in the attempts to develop these models. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:16:34