Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
alpha(2)-macroglobulin gene polymorphisms show racial diversity and are not associated with Alzheimer's disease
Autore:
Higuchi, S; Matsushita, S; Nakane, J; Arai, H; Matsui, T; Urakami, K; Yuzuriha, T; Takeda, A;
Indirizzi:
Kurihama Natl Hosp, Natl Inst Alcoholism, Div Clin Res, Yokosuka, Kanagawa2390841, Japan Kurihama Natl Hosp Yokosuka Kanagawa Japan 2390841 Kanagawa2390841, Japan Tohoku Univ, Sch Med, Dept Geriatr Med, Sendai, Miyagi 980, Japan Tohoku Univ Sendai Miyagi Japan 980 eriatr Med, Sendai, Miyagi 980, Japan Tohoku Univ, Sch Med, Dept Neurol, Sendai, Miyagi 980, Japan Tohoku Univ Sendai Miyagi Japan 980 ept Neurol, Sendai, Miyagi 980, Japan Tottori Univ, Sch Med, Dept Neurol, Tottori 680, Japan Tottori Univ Tottori Japan 680 Sch Med, Dept Neurol, Tottori 680, Japan Hizen Natl Hosp, Dept Psychiat, Saga, Japan Hizen Natl Hosp Saga JapanHizen Natl Hosp, Dept Psychiat, Saga, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 6, volume: 11, anno: 2000,
pagine: 1167 - 1171
SICI:
0959-4965(20000427)11:6<1167:AGPSRD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-RELATED PROTEIN; BETA-AMYLOID PEPTIDE; APOLIPOPROTEIN-E; ALPHA-2-MACROGLOBULIN GENE; DEMENTIA; BINDING;
Keywords:
Alzheimer's disease; apolipoprotein E; association study; Caucasian; Japanese; alpha(2)-macroglobulin; racial diversity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Higuchi, S Kurihama Natl Hosp, Natl Inst Alcoholism, Div Clin Res, 5-3-1 Nobi, Yokosuka, Kanagawa 2390841, Japan Kurihama Natl Hosp 5-3-1 Nobi Yokosuka Kanagawa Japan 2390841 n
Citazione:
S. Higuchi et al., "alpha(2)-macroglobulin gene polymorphisms show racial diversity and are not associated with Alzheimer's disease", NEUROREPORT, 11(6), 2000, pp. 1167-1171

Abstract

Two generic markers of the plasma protein alpha(2)-macroglobulin, a 5 bp deletion/insertion at the 5' splice site of exon 18 (A2M1) and the GTC/ATC (Val1000Ile) in exon 24 (A2M2), may have roles in the development of Alzheimer's disease (AD). Genotyping and linkage analysis of these markers in 426 Japanese sporadic AD patients, 85 autopsy-confirmed Caucasian AD cases, and, as controls, 382 Japanese and 65 Caucasians who were cognitively normal and 140 Japanese Parkinson's disease patients showed racial diversity in thefrequencies and relationship of the two markers. Comparison of genotype and allele frequencies, stratification of the samples by the presence of the apolipoprotein E epsilon 4 allele, and logistic regression analysis revealed no association of these markers with AD in either racial group. NeuroReport 11:1167-1171 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:05:16