Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Atrial fibrillation and the risk of cerebral white matter lesions
Autore:
de Leeuw, FE; de Groot, JC; Oudkerk, M; Kors, JA; Hofman, A; van Gijn, J; Breteler, MMB;
Indirizzi:
Erasmus Med Ctr Rotterdam, Daniel den Hoed Canc Clin, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, Netherlands Erasmus Med Ctr Rotterdam Rotterdam Netherlands NL-3000 DR , Netherlands Erasmus Med Ctr Rotterdam, Daniel den Hoed Canc Clin, Dept Med Informat, NL-3000 DR Rotterdam, Netherlands Erasmus Med Ctr Rotterdam Rotterdam Netherlands NL-3000 DR , Netherlands Erasmus Med Ctr Rotterdam, Daniel den Hoed Canc Clin, Dept Radiol, NL-3000DR Rotterdam, Netherlands Erasmus Med Ctr Rotterdam Rotterdam NetherlandsNL-3000 DR , Netherlands Univ Med Ctr Utrecht, Dept Neurol, Utrecht, Netherlands Univ Med Ctr Utrecht Utrecht Netherlands t Neurol, Utrecht, Netherlands
Titolo Testata:
NEUROLOGY
fascicolo: 9, volume: 54, anno: 2000,
pagine: 1795 - 1800
SICI:
0028-3878(20000509)54:9<1795:AFATRO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; CARDIOVASCULAR HEALTH; ALZHEIMERS-DISEASE; COGNITIVE FUNCTION; POPULATION; ROTTERDAM; DEMENTIA; MEN; ELECTROCARDIOGRAMS; HYPERINTENSITIES;
Keywords:
atrial fibrillation; white matter lesions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Breteler, MMB Erasmus Med Ctr Rotterdam, Daniel den Hoed Canc Clin, Dept Epidemiol & Biostat, POB 1738, NL-3000 DR Rotterdam, Netherlands Erasmus MedCtr Rotterdam POB 1738 Rotterdam Netherlands NL-3000 DR
Citazione:
F.E. de Leeuw et al., "Atrial fibrillation and the risk of cerebral white matter lesions", NEUROLOGY, 54(9), 2000, pp. 1795-1800

Abstract

Background: Cerebral white matter lesions are often observed on MRI scans of elderly nondemented and demented persons. Their pathogenesis is not fully understood but cerebral hypoperfusion may be involved. Atrial fibrillation is a common finding in elderly subjects and may lead to a reduced cardiacoutput with cerebral hypoperfusion. The authors investigated the association between atrial fibrillation and the presence of white matter lesions. Methods: From 1995 through 1996, the authors randomly sampled 1077 subjects from two ongoing prospective population-based studies. From each participant, an electrocardiogram (ECG) was recorded; atrial fibrillation and left ventricular hypertrophy were diagnosed with a computer program. For one of thetwo groups (553 subjects), earlier ECGs were available (mean follow-up 4.7years). All subjects underwent 1.5-T MRI scanning; white matter lesions were separately rated for the periventricular and subcortical regions. Results: The prevalence of atrial fibrillation was 1.9% among subjects younger than 75 years and 5.5% in subjects older than 75 years. The total number of subjects with atrial fibrillation was 28. Subjects with atrial fibrillation had severe periventricular white matter lesions more than twice as often assubjects who did not (RR 2.2; 95% CI 1.0 to 5.2) but had no increased riskof subcortical white matter lesions (RR 1.1; 95% CI 0.4 to 2.6). For sevensubjects with atrial fibrillation both at baseline and at follow up, theserelative risks were 6.3 (95% CI 1.1 to 37.1) and 0.7 (95% CT 0.1 to 3.7). Conclusions: Atrial fibrillation is associated with periventricular white matter lesions, but not with subcortical white matter lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 21:20:09