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Titolo:
Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development
Autore:
Sun, X; Lewandoski, M; Meyers, EN; Liu, YH; Maxson, RE; Martin, GR;
Indirizzi:
Univ Calif San Francisco, Sch Med, Dept Anat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Sch Med, Program Dev Biol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA USC Norris Canc Ctr, Dept Biochem & Mol Biol, Los Angeles, CA USA USC Norris Canc Ctr Los Angeles CA USA m & Mol Biol, Los Angeles, CA USA
Titolo Testata:
NATURE GENETICS
fascicolo: 1, volume: 25, anno: 2000,
pagine: 83 - 86
SICI:
1061-4036(200005)25:1<83:CIOFRC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
APICAL ECTODERMAL RIDGE; VERTEBRATE LIMB; SONIC-HEDGEHOG; FEEDBACK LOOP; MEDIATED RECOMBINATION; GENE-FUNCTION; MOUSE; EXPRESSION; GROWTH; OUTGROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Martin, GR Univ Calif San Francisco, Sch Med, Dept Anat, San Francisco, CA94143 USA Univ Calif San Francisco San Francisco CA USA 94143 94143 USA
Citazione:
X. Sun et al., "Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development", NAT GENET, 25(1), 2000, pp. 83-86

Abstract

Development of the vertebrate limb bud depends on reciprocal interactions between the zone of polarizing activity (ZPA) and the apical ectodermal ridge(1) (AER). Sonic hedgehog (SHH) and fibroblast growth factors (FGFs) are key signalling molecules produced in the ZPA and AER, respectively(1,2). Experiments in chicks suggested that SHH expression in the ZPA is maintained by FGF4 expression in the AER, acid vice versa(3,4), providing a molecular mechanism for coordinating the activities of these two signalling centres. This SHH/FGF4 feedback loop model is supported by genetic evidence showing that Fgf4 expression is not maintained in Shh(-/-) mouse limbs(5). We report here that Shh expression is maintained and limb formation is normal when Fgf4 is inactivated in mouse limbs, thus contradicting the model. We also found that maintenance of Fgf9 and Fgf17 expression is dependent on Shh, whereas Fgf8 expression is not. We discuss a model in which no individual Fgf expressed in the AER (AER-Fgf) is solely necessary to maintain Shh expression, but, instead, the combined activities of two or more AER-Fgfs function in a positive feedback loop with Shh to control limb development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 03:46:53