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Titolo:
Diet drug-related cardiac valve disease: The Mayo Clinic EchocardiographicLaboratory experience
Autore:
Teramae, CY; Connolly, HM; Grogan, M; Miller, FA;
Indirizzi:
Mayo Clin Rochester, Div Cardiovasc Dis & Internal Med, Rochester, MN USA Mayo Clin Rochester Rochester MN USA s & Internal Med, Rochester, MN USA
Titolo Testata:
MAYO CLINIC PROCEEDINGS
fascicolo: 5, volume: 75, anno: 2000,
pagine: 456 - 461
SICI:
0025-6196(200005)75:5<456:DDCVDT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
APPETITE-SUPPRESSANT DRUGS; PRIMARY PULMONARY-HYPERTENSION; OBESE PATIENTS; REGURGITATION; FENFLURAMINE; PREVALENCE; DEXFENFLURAMINE; PHENTERMINE; INSUFFICIENCY; DETERMINANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Connolly, HM Mayo Clin Rochester, Div Cardiovasc Dis, 200 1st St SW, Rochester, MN 55905 USA Mayo Clin Rochester 200 1st St SW Rochester MN USA 55905 USA
Citazione:
C.Y. Teramae et al., "Diet drug-related cardiac valve disease: The Mayo Clinic EchocardiographicLaboratory experience", MAYO CLIN P, 75(5), 2000, pp. 456-461

Abstract

Objective: To describe the prevalence of diet drug-related valvular disease among our referral population and the association of valvular disease with duration of exposure to fenfluramine and phentermine in combination and to dexfenfluramine alone. Patients and Methods: In this retrospective review of clinical and echocardiographic data, charts of patients referred for treatment of toxic effectsof diet drugs were reviewed, and telephone interviews were conducted. Results: Between June and December 1997, 191 patients (164 women, 27 men; mean age, 47 years) were referred for possible diet drug-related valvular disease. Twenty-eight (28%) of the 99 asymptomatic patients and 40 (43%) of the 92 symptomatic patients had abnormal echocardiographic findings. Valvular lesions among the 68 patients with abnormal echocardiographic findings included mild (or greater) aortic regurgitation in 55 patients (81%), moderate (or greater) mitral regurgitation in 12 (18%), and moderate (or greater)tricuspid regurgitation in 7 (10%), The Food and Drug Administration case definition of diet drug-related valvulopathy was noted in 31% of this referral population. Of patients with valvulopathy, mean duration of therapy with fefluramine and phentermine in combination and dexfenfluramine alone was 9 months and 5 months, respectively. Duration of therapy was not associatedwith presence or absence of disease. Five patients had surgical intervention for severe valvulopathy: 3 had mitral valve repair, I had mitral valve replacement, and 1 had aortic valve replacement. Pulmonary hypertension (greater than or equal to 40 mm Hg) was found in 24 patients (13%), and 17 (71%) had pulmonary hypertension in association with valvulopathy,Conclusion: This study demonstrated a 31% (60/191) prevalence of valvulopathy in patients with a history of diet drug exposure who were referred for echocardiographic evaluation, The most common finding was mild aortic regurgitation, Twenty-eight percent of asymptomatic patients had abnormal echocardiographic findings. This study emphasizes the spectrum of diet drug-related cardiac disease and the potential for valvulopathy in asymptomatic patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:25:07