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Titolo:
Estrogen replacement therapy and MRI-demonstrated cerebral infarcts, whitematter changes, and brain atrophy in older women: The Cardiovascular Health Study
Autore:
Luoto, R; Manolio, T; Meilahn, E; Bhadelia, R; Furberg, C; Cooper, L; Kraut, M;
Indirizzi:
Natl Publ Hlth Inst, Dept Hlth & Disabil, FIN-00300 Helsinki, Finland NatlPubl Hlth Inst Helsinki Finland FIN-00300 N-00300 Helsinki, Finland NHLBI, NIH, Bethesda, MD USA NHLBI Bethesda MD USANHLBI, NIH, Bethesda, MD USA London Sch Hyg & Trop Med, Dept Epidemiol & Publ Hlth, London WC1, EnglandLondon Sch Hyg & Trop Med London England WC1 l Hlth, London WC1, England Tufts New England Med Ctr, Ultrasound Reading Ctr, Boston, MA USA Tufts New England Med Ctr Boston MA USA ound Reading Ctr, Boston, MA USA Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA Wake Forest Univ Winston Salem NC USA ray Sch Med, Winston Salem, NC USA Johns Hopkins Radiol, Baltimore, MD USA Johns Hopkins Radiol Baltimore MDUSA Hopkins Radiol, Baltimore, MD USA
Titolo Testata:
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
fascicolo: 5, volume: 48, anno: 2000,
pagine: 467 - 472
SICI:
0002-8614(200005)48:5<467:ERTAMC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
RISK-FACTORS; POSTMENOPAUSAL WOMEN; COGNITIVE FUNCTION; ALZHEIMERS-DISEASE; LESIONS; ATHEROSCLEROSIS; ABNORMALITIES; PREVALENCE; ROTTERDAM; GENDER;
Keywords:
estrogen; magnetic resonance imaging; population study; MMSE; hormone replacement therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Luoto, R Natl Publ Hlth Inst, Dept Hlth & Disabil, Mannerheimintie 166, FIN-00300 Helsinki, Finland Natl Publ Hlth Inst Mannerheimintie 166 HelsinkiFinland FIN-00300
Citazione:
R. Luoto et al., "Estrogen replacement therapy and MRI-demonstrated cerebral infarcts, whitematter changes, and brain atrophy in older women: The Cardiovascular Health Study", J AM GER SO, 48(5), 2000, pp. 467-472

Abstract

OBJECTIVE: We studied the relationship between the use of estrogen replacement therapy (ERT) and cerebral magnetic resonance imaging (MRI) abnormalities among older women. DESIGN: A population-based prospective study (Cardiovascular Health Study). SETTING: Four regions in the United States. PARTICIPANTS: A total of 2133 (62.9% of the eligible) women aged 65 to 95 years (mean age 74.8), on whom MRI was performed in 1992-1994. MEASUREMENTS: Presence of global brain atrophy, white matter changes, small infarct-like lesion (ILL) (<3 mm), MRI infarcts (greater than or equal to3 mm, mostly small and asymptomatic), and cognitive function as measured by Mini-Mental State Exam (MMSE), and by ERT use (current/past/never), adjusted for a number of socioeconomic, lifestyle, and reproductive covariates. RESULTS: Current use of ERT was reported by 15% and past use by another 23% of participants; 35% of all women had MRI infarcts. The prevalence of MRIinfarcts did not differ in current or past users from those who had never used ERT (nonusers). Bifrontal distance, the largest distance between frontal horns, and the size of ventricles were larger among current ERT users compared to past users or nonusers (P (trend) =.01), adjusted for all other covariates, but no dose-response relationship to current or past ERT use wasfound. Duration of estrogen use was not associated with any atrophy measure. Cortical atrophy measure, sulcal widening, or white matter disease did not differ significantly by ERT use or duration of use. Central measures of atrophy, bifrontal distance, and ventricular size were significantly associated with cognition as measured by MMSE. CONCLUSIONS: Current ERT users had much more clinically significant central atrophy than nonusers, but the implications remained unclear. J Am Geriatr Soc 48:467-472, 2000.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:25:14