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Titolo:
Upregulation of human cytotrophoblast invasion by hepatocyte growth factor
Autore:
Nasu, K; Zhou, Y; McMaster, MT; Fisher, SJ;
Indirizzi:
Univ Calif San Francisco, Dept Stomatol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco,CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco,CA 94143 USA Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Oita Med Univ, Dept Obstet & Gynecol, Oita 8795593, Japan Oita Med Univ Oita Japan 8795593 t Obstet & Gynecol, Oita 8795593, Japan
Titolo Testata:
JOURNAL OF REPRODUCTION AND FERTILITY
, , anno: 2000, supplemento:, 55
pagine: 73 - 80
SICI:
0022-4251(2000):<73:UOHCIB>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR SCATTER FACTOR; RECEPTOR C-MET; GESTATIONAL-AGE INFANTS; HUMAN PLACENTA; ENDOVASCULAR INVASION; ADHESION RECEPTORS; PRE-ECLAMPSIA; FACTOR HGF; IN-VITRO; PREECLAMPSIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Nasu, K Univ Calif San Francisco, Dept Stomatol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 CA 94143 USA
Citazione:
K. Nasu et al., "Upregulation of human cytotrophoblast invasion by hepatocyte growth factor", J REPR FERT, 2000, pp. 73-80

Abstract

Mesenchymal-epithelial interactions exert powerful influences on tissue architecture. At the molecular level, hepatocyte growth factor (HGF; producedby mesenchyme) and its c-met tyrosine kinase receptor (expressed on epithelial cells) participate in this paracrine dialogue. Zn the present study, anti-HGF immunoreactivity was usually detected in association with the mesenchymal cores of chorionic villi in situ, whereas cytotrophoblasts (CTBs) stained for c-met. Ln pre-eclampsia, mesenchymal HGF staining was either verylow or was not observed, whereas CTB c-met expression was unchanged compared with control samples. These findings suggest that faulty signals emanating from the villus mesenchyme may contribute to the failure of CTB invasionthat is associated with pre-eclampsia. In the present study, this hypothesis was tested and it was found that HGF treatment stimulates CTB invasion in vitro by four times. These immunolocalization and functional data indicate that HGF-c-met interactions play a key role in regulating the depth of CTB invasion in normal pregnancy and preeclampsia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 20:19:22