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Titolo:
Providing progesterone for pregnancy: control of cholesterol flux to the side-chain cleavage system
Autore:
Strauss, JF; Christenson, LK; Devoto, L; Martinez, F;
Indirizzi:
Univ Penn, Sch Med, Ctr Res Reprod & Womens Hlth, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 mens Hlth, Philadelphia, PA 19104 USA
Titolo Testata:
JOURNAL OF REPRODUCTION AND FERTILITY
, , anno: 2000, supplemento:, 55
pagine: 3 - 12
SICI:
0022-4251(2000):<3:PPFPCO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE REGULATORY PROTEIN; LIPOID ADRENAL-HYPERPLASIA; PROMOTER ACTIVITY; STAR GENE; TRANSCRIPTIONAL REGULATION; STEROIDOGENIC FACTOR-1; FOLLICULAR DEVELOPMENT; TARGETED DISRUPTION; C/EBP-ALPHA; RAT OVARY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Strauss, JF Univ Penn, Sch Med, Ctr Res Reprod & Womens Hlth, 1354 Biomed Res Bldg II-III,421 Curie Blvd, Philadelphia, PA 19104 USA Univ Penn 1354 Biomed Res Bldg II-III,421 Curie Blvd Philadelphia PA USA 19104
Citazione:
J.F. Strauss et al., "Providing progesterone for pregnancy: control of cholesterol flux to the side-chain cleavage system", J REPR FERT, 2000, pp. 3-12

Abstract

Progesterone, which is required to support human gestation, is derived initially from the corpus luteum and subsequently from the placenta. The rate-limiting step in progesterone synthesis is the delivery of cholesterol to the mitochondrial cholesterol side-chain cleavage system. The steroidogenic acute regulatory protein (StAR) mediates this process in the corpus luteum,whereas in the placenta, which does not express StAR, a StAR homologue, MLN64, may accomplish this function. StAR expression is regulated in the ovary at the transcriptional level by a cAMP-activated signal transduction system and StAR activity is also increased acutely by protein kinase A-mediatedphosphorylation. These long-term (transcriptional) and short-term (post-translational, that is, phosphorylation) mechanisms govern luteal steroidogenic activity The StAR protein has two key functional domains. The StAR C-terminal domain increases cholesterol movement to cytochrome P450scc by promoting sterol desorption from the sterol-rich outer mitochondrial membrane, driving it to the relatively sterol-poor inner membrane. The N-terminal domain mitochondrial targeting sequence directs the StAR protein to the mitochondria.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 15:31:20