Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Evidence of elevated intracellular calcium levels in weaver homozygote mice
Autore:
Harkins, AB; Dlouhy, S; Ghetti, B; Cahill, AL; Won, L; Heller, B; Heller, A; Fox, AP;
Indirizzi:
Univ Chicago, Dept Neurobiol Pharmacol & Physiol Sci, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 ol & Physiol Sci, Chicago, IL 60637 USA Indiana Univ, Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 Genet, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 ab Med, Indianapolis, IN 46202 USA
Titolo Testata:
JOURNAL OF PHYSIOLOGY-LONDON
fascicolo: 2, volume: 524, anno: 2000,
pagine: 447 - 455
SICI:
0022-3751(20000415)524:2<447:EOEICL>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL RAPHE NEURONS; CEREBELLAR GRANULE NEURONS; RECTIFYING K+ CHANNELS; G-PROTEIN; INWARD RECTIFIER; MUTANT MICE; DOPAMINE DEFICIENCY; POTASSIUM CHANNELS; MESSENGER-RNAS; PURKINJE-CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Harkins, AB Univ Chicago, Dept Neurobiol Pharmacol & Physiol Sci, 947 E 58th St, Chicago, IL 60637 USA Univ Chicago 947 E 58th St Chicago IL USA 60637 , IL 60637 USA
Citazione:
A.B. Harkins et al., "Evidence of elevated intracellular calcium levels in weaver homozygote mice", J PHYSL LON, 524(2), 2000, pp. 447-455

Abstract

1. A mutation in the G-protein-linked, inwardly rectifying K+ channel GIRK2 leads to the loss of cerebellar and dopaminergic mesencephalic neurons inweaver mice. The steps leading to cell death are not well understood but may involve constitutive influx of Na+ and Ca2+ into the neurons.2. We found that resting [Ca2+](i) was dramatically higher in cerebellar neurons from weaver mice compared to wild-type neurons.3. High-K+ stimuli elicited much smaller changes in [Ca2+](i) in weaver cerebellar neurons compared to wild-type neurons.4. weaver cerebellar granule cells could be rescued from cell death by theGIRK2wv cationic channel blocker, QX-314.5. QX-314 lowered resting intracellular Ca2+ levels in weaver cerebellar granule cells.6. These results suggest that changes in resting [Ca2+](i) levels and alterations in K+ channel function are most likely to contribute to the developmental abnormalities and increased cerebellar cell death observed in weavermice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 13:05:24