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Titolo:
Cholinergic excitation of septohippocampal GABA but not cholinergic neurons: Implications for learning and memory
Autore:
Wu, M; Shanabrough, M; Leranth, C; Alreja, M;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06508 USA Yale Univ New Haven CT USA 06508 , Dept Psychiat, New Haven, CT 06508 USA Yale Univ, Sch Med, Dept Obstet & Gynecol, New Haven, CT 06508 USA Yale Univ New Haven CT USA 06508 bstet & Gynecol, New Haven, CT 06508 USA Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06508 USA Yale Univ NewHaven CT USA 06508 Dept Neurobiol, New Haven, CT 06508 USA Connecticut Mental Hlth Ctr, Abraham Ribicoff Res Facil, New Haven, CT 06508 USA Connecticut Mental Hlth Ctr New Haven CT USA 06508 ew Haven, CT 06508 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 10, volume: 20, anno: 2000,
pagine: 3900 - 3908
SICI:
0270-6474(20000515)20:10<3900:CEOSGB>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEPTUM-DIAGONAL BAND; MUSCARINIC ACETYLCHOLINE-RECEPTOR; HIPPOCAMPAL THETA-RHYTHM; GROWTH-FACTOR RECEPTOR; MEDIAL SEPTUM; BASAL FOREBRAIN; WORKING-MEMORY; ALZHEIMERS-DISEASE; GABAERGIC NEURONS; INTRACELLULAR-RECORDINGS;
Keywords:
theta rhythm; 192IgG; p75 receptor; neurotrophin; acetylcholine; memory; cognition; disinhibition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Alreja, M Yale Univ, Sch Med, Dept Psychiat, CMHC 335A,34 Pk St, New Haven, CT 06508USA Yale Univ CMHC 335A,34 Pk St New Haven CT USA 06508 CT 06508USA
Citazione:
M. Wu et al., "Cholinergic excitation of septohippocampal GABA but not cholinergic neurons: Implications for learning and memory", J NEUROSC, 20(10), 2000, pp. 3900-3908

Abstract

The medial septum/diagonal band (MSDB), which gives rise to the septohippocampal pathway, is a critical locus for the mnemonic effects of muscarinic drugs. Infusion of muscarinic cholinergic agonists into the MSDB enhance learning and memory processes both in young and aged rats and produce a continuous theta rhythm in the hippocampus. Intraseptal muscarinic agonists alsoalleviate the amnesic syndrome produced by systemic administration of muscarinic receptor antagonists. It has been presumed, but not proven, that thecellular mechanisms underlying the effects of muscarinic agonists in the MSDB involve an excitation of septohippocampal cholinergic neurons and a subsequent increase in acetylcholine (ACh) release in the hippocampus. Using anovel fluorescent labeling technique to selectively visualize live septohippocampal cholinergic neurons in rat brain slices, we have found that muscarinic agonists do not excite septohippocampal cholinergic neurons, instead they inhibit a subpopulation of cholinergic neurons. In contrast, unlabeledneurons, confirmed to be noncholinergic, septohippocampal GABA-type neurons using retrograde marking and double-labeling techniques, are profoundly excited by muscarine. Thus, the cognition-enhancing effects of muscarinic drugs in the MSDB cannot be attributed to an increase in hippocampal ACh release. Instead, disinhibitory mechanisms, caused by increased impulse flow inthe septohippocampal GABAergic pathway, may underlie the cognition-enhancing effects of muscarinic agonists.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 11:01:04