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Titolo:
Possible involvement of undissociated acid molecules in the acid response of the chorda tympani nerve of the rat
Autore:
Ogiso, K; Shimizu, Y; Watanabe, K; Tonosaki, K;
Indirizzi:
Gifu Univ, Fac Agr, Dept Vet Physiol, Gifu 5011193, Japan Gifu Univ GifuJapan 5011193 Agr, Dept Vet Physiol, Gifu 5011193, Japan
Titolo Testata:
JOURNAL OF NEUROPHYSIOLOGY
fascicolo: 5, volume: 83, anno: 2000,
pagine: 2776 - 2779
SICI:
0022-3077(200005)83:5<2776:PIOUAM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TASTE CELLS; SOUR TASTE; TRANSDUCTION; RECEPTOR; CONDUCTANCE; AMILORIDE; CHANNELS; MOUSE; NACL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Tonosaki, K Gifu Univ, Fac Agr, Dept Vet Physiol, Gifu 5011193, Japan GifuUniv Gifu Japan 5011193 et Physiol, Gifu 5011193, Japan
Citazione:
K. Ogiso et al., "Possible involvement of undissociated acid molecules in the acid response of the chorda tympani nerve of the rat", J NEUROPHYS, 83(5), 2000, pp. 2776-2779

Abstract

To test whether undissociated acid is capable of exciting the chorda tympani nerves in rats, we have used buffered acid solutions as taste stimuli. These solutions were prepared by adding alkali to weak acids, such as aceticacid, so that the proportion of undissociated and dissociated acids was varied whereas keeping the total acid concentration constant. When acetic acid solutions, adjusted to wide ranges of pH by NaOH, were applied to the tongue, the response magnitude of the chorda tympani nerves was not varied systematically with pH changes. However, if the sodium effect was eliminated by amiloride or replacement of cation by potassium or Tris[hydroxymethyl]aminomethane; NH2C(CH2OH)(3) (Tris-base), the chorda tympani response was reduced systematically as pH increased. Similar results were obtained with citric acid and ascorbic acid. This pH-dependent change in taste nerve responseto acid cannot be solely attributed to the proton gradient because the response magnitude induced by hydrogen itself, which was estimated from responses to strong acids, was much smaller than that by equi-pH acetic acid (similar to 85%). Thus we cannot explain the pH-dependent responses of the chorda tympani nerves to weak acids unless effects of undissociated acid molecules are postulated. It is therefore concluded that undissociated acids in weak acid solutions can be a stimulant to taste receptor cells.

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Documento generato il 13/07/20 alle ore 11:10:19