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Titolo:
Mannose 6-phosphate/insulin-like growth factor 2 receptor, a Bona fide tumor suppressor gene or just a promising candidate?
Autore:
DaCosta, SA; Schumaker, LM; Elli, MJ;
Indirizzi:
Georgetown Univ, Lombardi Canc Ctr, Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 anc Ctr, Washington, DC 20007 USA
Titolo Testata:
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
fascicolo: 1, volume: 5, anno: 2000,
pagine: 85 - 94
SICI:
1083-3021(200001)5:1<85:M6GF2R>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-II RECEPTOR; II/MANNOSE 6-PHOSPHATE RECEPTOR; FACTOR TYPE-2 RECEPTOR; IGF-II; MICROSATELLITE INSTABILITY; UROKINASE RECEPTOR; LIGAND-BINDING; MANNOSE-6-PHOSPHATE RECEPTOR; MISSENSE MUTATIONS; BREAST CARCINOMAS;
Keywords:
mannose 6-phosphate/insulin-like growth factor 2 receptor; tumor suppressor gene; breast cancer; loss of heterozygosity; somatic mutation; microsatellite instability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Elli, MJ Georgetown Univ, Lombardi Canc Ctr, Room E518,Res Bldg,3970 Reservoir Rd NW, Washington, DC 20007 USA Georgetown Univ Room E518,Res Bldg,3970 Reservoir Rd NW Washington DC USA 20007
Citazione:
S.A. DaCosta et al., "Mannose 6-phosphate/insulin-like growth factor 2 receptor, a Bona fide tumor suppressor gene or just a promising candidate?", J MAMMARY G, 5(1), 2000, pp. 85-94

Abstract

The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/ICF2R)(3) is considered a "candidate" tumor suppressor gene. This hypothesis has been provoked by the identification of loss of heterozygosity (LOH) at the M6P/IGF2R locus on chromosome 6q26 in breast and liver cancer, accompanied by point mutations in the remaining allele. Somatic mutations in coding region microsatellites have also been described in replication error positive (RER+) tumors of the gastrointestinal tract, endometrium and brain. These genetic data are compelling, but a tumor suppressor gene candidate has to meet functional as well as genetic criteria. This review weighs the evidence and discusses the observations that are necessary to promote M6P/ICF2R from candidate to bona fide tumor suppressor gene.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 13:03:02