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Titolo:
The EWA (Estrogen in Women with Atherosclerosis) Study: a randomized studyof the use of hormone replacement therapy in women with angiographically verified coronary artery disease. Characteristics of the study population. Effects on lipids and lipoproteins
Autore:
Os, I; Hofstad, AE; Brekke, M; Abdelnoor, M; Nesheim, BI; Jacobsen, AF; Birkeland, K; Larsen, A; Midtbo, K; Westheim, A;
Indirizzi:
Ulleval Univ Hosp, Dept Med, N-0407 Oslo, Norway Ulleval Univ Hosp Oslo Norway N-0407 Hosp, Dept Med, N-0407 Oslo, Norway Ulleval Univ Hosp, Dept Cardiovasc Radiol & Intervent, N-0407 Oslo, NorwayUlleval Univ Hosp Oslo Norway N-0407 ol & Intervent, N-0407 Oslo, Norway Ulleval Univ Hosp, Dept Clin Epidemiol, Res Forum, N-0407 Oslo, Norway Ulleval Univ Hosp Oslo Norway N-0407 iol, Res Forum, N-0407 Oslo, Norway Ulleval Univ Hosp, Dept Obstet & Gynaecol, N-0407 Oslo, Norway Ulleval Univ Hosp Oslo Norway N-0407 tet & Gynaecol, N-0407 Oslo, Norway Aker Univ Hosp, Hormone Lab, Oslo, Norway Aker Univ Hosp Oslo NorwayAker Univ Hosp, Hormone Lab, Oslo, Norway
Titolo Testata:
JOURNAL OF INTERNAL MEDICINE
fascicolo: 4, volume: 247, anno: 2000,
pagine: 433 - 441
SICI:
0954-6820(200004)247:4<433:TE(IWW>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTMENOPAUSAL WOMEN; MYOCARDIAL-INFARCTION; HEART-DISEASE; PLASMA; RISK; HYPERCHOLESTEROLEMIA; PRAVASTATIN; CHOLESTEROL; MENOPAUSE; PROGESTIN;
Keywords:
coronary artery disease; lipids; women;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Os, I Ulleval Univ Hosp, Dept Med, N-0407 Oslo, Norway Ulleval Univ Hosp Oslo Norway N-0407 Dept Med, N-0407 Oslo, Norway
Citazione:
I. Os et al., "The EWA (Estrogen in Women with Atherosclerosis) Study: a randomized studyof the use of hormone replacement therapy in women with angiographically verified coronary artery disease. Characteristics of the study population. Effects on lipids and lipoproteins", J INTERN M, 247(4), 2000, pp. 433-441

Abstract

Objectives. To evaluate the effects of hormone replacement therapy (HRT) on lipids and lipoproteins in postmenopausal women with coronary artery disease. Setting. In this single-centre, controlled and randomized study taking place in a tertiary referral clinic, patients were examined at baseline, and after 3 and 12 months. All analyses were performed examiner-blind. Subjects. Postmenopausal women (n = 118) with angiographically verified coronary artery disease were recruited consecutively from patients referred for investigational procedures due to coronary artery disease. Interventions. The women were randomized to HRT, i.e. transdermal application of continuous 17-beta oestradiol with cyclic medroxyprogesterone actetate tablets every 3rd month for 14 days, or to a control group. Main outcomes. Effects on lipids and lipoproteins. Results. After 3 months of unopposed oestradiol, triglycerides decreased significantly compared to the control group (P = 0.006). Sequential administration of medroxyprogesterone caused a decrease in HDL cholesterol (P = 0.01), concomitantly with a decrease in ApoA1 lipoproteins (P = 0.007). No other changes in lipids or lipoproteins were observed. After 12 months of therapy, no significant differences were observed between the two groups in lipid or lipoprotein levels. Concomitant statin treatment did not alter the main findings. Conclusions. In postmenopausal women with established coronary artery disease in whom the majority is treated with statins, no additional effect of HRT on lipids or lipoproteins could be observed except for a transient decrease in triglycerides in the initial unopposed oestradiol phase. No deleterious effect could be observed during medroxyprogesterone administration except for a small transient decrease in HDL cholesterol and ApoA1 lipoproteins.

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Documento generato il 04/04/20 alle ore 01:36:08