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Titolo:
Analysis of successful immune responses in persons infected with hepatitisC virus
Autore:
Lechner, F; Wong, DKH; Dunbar, PR; Chapman, R; Chung, RT; Dohrenwend, P; Robbins, G; Phillips, R; Klenerman, P; Walker, BD;
Indirizzi:
Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Med, Oxford OX3 9DU, England Univ Oxford Oxford England OX3 9DU ept Clin Med, Oxford OX3 9DU, England Univ Oxford, John Radcliffe Hosp, MRC, Human Immunol Unit, Oxford OX3 9DU,England Univ Oxford Oxford England OX3 9DU Immunol Unit, Oxford OX3 9DU,England Massachusetts Gen Hosp, Gastrointestinal Unit, Boston, MA 02129 USA Massachusetts Gen Hosp Boston MA USA 02129 nal Unit, Boston, MA 02129 USA Massachusetts Gen Hosp, Infect Dis Unit, Boston, MA 02129 USA Massachusetts Gen Hosp Boston MA USA 02129 Dis Unit, Boston, MA 02129 USA Massachusetts Gen Hosp, AIDS Res Ctr, Boston, MA 02129 USA Massachusetts Gen Hosp Boston MA USA 02129 Res Ctr, Boston, MA 02129 USA Harvard Univ, Sch Med, Boston, MA 02129 USA Harvard Univ Boston MA USA 02129 vard Univ, Sch Med, Boston, MA 02129 USA
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 9, volume: 191, anno: 2000,
pagine: 1499 - 1512
SICI:
0022-1007(20000501)191:9<1499:AOSIRI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOTOXIC T-LYMPHOCYTES; MHC CLASS-I; CHORIOMENINGITIS VIRUS; PERIPHERAL-BLOOD; ANTIRETROVIRAL THERAPY; QUANTITATIVE-ANALYSIS; PHENOTYPIC ANALYSIS; VIRAL CLEARANCE; CELL RESPONSE; HIV-INFECTION;
Keywords:
acute infection; cytotoxic T lymphocytes; T helper cells; tetramer staining; interferon gamma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Klenerman, P Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Med, Level 7, Oxford OX3 9DU, England Univ Oxford Level 7 Oxford England OX3 9DU OX3 9DU, England
Citazione:
F. Lechner et al., "Analysis of successful immune responses in persons infected with hepatitisC virus", J EXP MED, 191(9), 2000, pp. 1499-1512

Abstract

Although hepatitis C virus (HCV) infection is very common, identification of patients during acute infection is rare. Consequently, little is known about the immune response during this critical stage of the disease. We analyzed the T lymphocyte response during and after acute resolving HCV infection in three persons, using interferon (IFN)-gamma enzyme-linked immunospot (ELISPOT) and human histocompatibility leukocyte antigen (HLA) peptide tetramer assays. Acute infection was associated with a broadly directed T helper and cytotoxic T lymphocyte (CTL) response, which persisted after resolution of clinical hepatitis and clearance of viremia. At the earliest time point studied, highly activated CTL populations were observed that temporarilyfailed to secrete IFN-gamma, a "stunned" phenotype, from which they recovered as viremia declined, in long-term HCV-seropositive persons, CTL responses were more common in persons who had cleared viremia compared with those with persistent viremia, although the frequencies of HCV-specific CTLs werelower than those found in persons during and after resolution of acute HCVinfection. These studies demonstrate a strong and persistent CTL response in resolving acute HCV infection, and provide rationale to explore immune augmentation as a therapeutic intervention in chronic HCV infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:04:12