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Titolo:
Alymphoplasia (aly)-type nuclear factor kappa B-inducing kinase (NIK) causes defects in secondary lymphoid tissue chemokine receptor signaling and homing of peritoneal cells to the gut-associated lymphatic tissue system
Autore:
Fagarasan, S; Shinkura, R; Kamata, T; Nogaki, F; Ikuta, K; Tashiro, K; Honjo, T;
Indirizzi:
Kyoto Univ, Fac Med, Dept Med Chem, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 Med Chem, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ, Ctr Mol Biol & Genet, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 tr Mol Biol & Genet, Kyoto 6068501, Japan
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 9, volume: 191, anno: 2000,
pagine: 1477 - 1486
SICI:
0022-1007(20000501)191:9<1477:A(NFKB>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-COUPLED RECEPTOR; TUMOR-NECROSIS-FACTOR; ALPHA-DEFICIENT MICE; IGA PLASMA-CELLS; ALY MUTANT MICE; LYMPHOTOXIN-ALPHA; PEYERS-PATCHES; ORGAN DEVELOPMENT; GERMINAL-CENTERS; IMMUNE-RESPONSE;
Keywords:
RAG-2(-/-) mice; peritoneal cavity cell transfer; lamina propria; IgA plasma cells; chemotaxis assay;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Honjo, T Kyoto Univ, Fac Med, Dept Med Chem, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 , Sakyo Ku, Kyoto 6068501, Japan
Citazione:
S. Fagarasan et al., "Alymphoplasia (aly)-type nuclear factor kappa B-inducing kinase (NIK) causes defects in secondary lymphoid tissue chemokine receptor signaling and homing of peritoneal cells to the gut-associated lymphatic tissue system", J EXP MED, 191(9), 2000, pp. 1477-1486

Abstract

Alymphoplasia (aly) mice, which carry a point mutation in the nuclear factor kappa B-inducing kinase (NIK) gene, are characterized by the systemic absence of lymph nodes and Peyer's patches, disorganized splenic and thymic architectures, and immunodeficiency. Another unique feature of aly/aly mice is that their peritoneal cavity contains more B1 cells than normal and aly/ mice. Transfer experiments of peritoneal lymphocytes from aly/aly mice into recombination activating gene (RAG)-2(-/-) mice revealed that B and T cells fail to migrate to other lymphoid tissues, particularly to the gut-associated lymphatic tissue system. In vivo homing defects of aly/aly peritoneal cells correlated with reduction of their in vitro chemotactic responses to secondary lymphoid tissue chemokine (SLC) and B lymphocyte chemoattractant (BLC). The migration defect of aly/aly lymphocytes was not due to a lack of expression of chemokines and their receptors, but rather to impaired signal transduction downstream of the receptors for SLC, indicating that NIK is involved in the chemokine signaling pathway known to couple only with G proteins. The results showed that the reduced serum levels of immunoglobulins (Igs) and the absence of class switch to IgA in aly/aly mice are due, at least in part, to a migration defect of lymphocytes to the proper microenvironment where B cells proliferate and differentiate into Ig-producing cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:35:48