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Titolo:
Sigmoid ischemia and the inflammatory response following endovascular abdominal aortic aneurysm repair
Autore:
Elmarasy, NM; Soong, CV; Walker, SR; Macierewicz, JA; Yusuf, SW; Wenham, PW; Hopkinson, BR;
Indirizzi:
Queens Med Ctr, Dept Vasc & Endovasc Surg, Nottingham NG7 2UH, England Queens Med Ctr Nottingham England NG7 2UH g, Nottingham NG7 2UH, England
Titolo Testata:
JOURNAL OF ENDOVASCULAR THERAPY
fascicolo: 1, volume: 7, anno: 2000,
pagine: 21 - 30
SICI:
1526-6028(200002)7:1<21:SIATIR>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIOLOGICAL RESPONSES; REPERFUSION INJURY; BOWEL ISCHEMIA; INTRAMURAL PH; SURGERY; ENDOTOXIN; COLON; COMPLICATIONS; INTERLEUKIN-6; OPERATIONS;
Keywords:
endotoxemia; cytokines; pyrexia; ischemia-reperfusion injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Elmarasy, NM Queens Med Ctr, Dept Vasc & Endovasc Surg, Nottingham NG7 2UH, England Queens Med Ctr Nottingham England NG7 2UH NG7 2UH, England
Citazione:
N.M. Elmarasy et al., "Sigmoid ischemia and the inflammatory response following endovascular abdominal aortic aneurysm repair", J ENDOVAS T, 7(1), 2000, pp. 21-30

Abstract

Purpose: To assess the relationship between sigmoid colonic perfusion, endotoxemia, and cytokine generation in patients undergoing elective open repair (OR) or endovascular repair (EVR) of infrarenal abdominal aortic aneurysms (AAA). Methods: Ten patients (9 males; average age 67.6 +/- 2.5 years, mean aneurysm diameter 6.9 +/- 0.6 cm) undergoing OR were compared to 10 patients (all males; average age 70.3 +/- 2.6 years, mean aneurysm diameter 6.5 +/- 0.5cm) whose repair was performed using the EVR technique. The partial pressure of the carbon dioxide gap (PCO2gap = tissue PCO2 - arterial PCO2,) of the sigmoid colonic mucosa was measured using a silicone tonometer to evaluate bower perfusion. Blood samples were collected into pyrogen-free heparinized tubes for quantification of plasma concentrations of endotoxin, tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6) before, during, and after aortic repair. Results: Patients in the OR group had a significantly greater increase in PCO2gap, suggesting a greater degree of bowel ischemia compared to the EVR group. This was associated with significantly greater postoperative concentrations of endotoxin, TNF-alpha, and IL-6 in the OR group. A significant correlation was found between PCO2gap, IL-6, and postoperative core temperature. Conclusions: The results suggest that the degree of bowel ischemia, endotoxemia, and cytokine generation following elective infrarenal AAA reconstruction may be reduced if the endovascular technique is used instead of conventional surgery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 09:05:46