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Titolo:
IL-10-producing T cells suppress immune responses in anergic tuberculosis patients
Autore:
Boussiotis, VA; Tsai, EY; Yunis, EJ; Thim, S; Delgado, JC; Dascher, CC; Berezovskaya, A; Rousset, D; Reynes, JM; Goldfeld, AE;
Indirizzi:
Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA Dana Farber Canc Inst Boston MA USA 02115 ult Oncol, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med Oncol, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 Med Oncol, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 Dept Med, Boston, MA 02115 USA Ctr Blood Res, Boston, MA 02115 USA Ctr Blood Res Boston MA USA 02115Ctr Blood Res, Boston, MA 02115 USA Dana Farber Canc Inst, Div Immunol & AIDS, Boston, MA 02115 USA Dana Farber Canc Inst Boston MA USA 02115 ol & AIDS, Boston, MA 02115 USA Cambodian Hlth Comm, Phnom Penh, Cambodia Cambodian Hlth Comm Phnom PenhCambodia Hlth Comm, Phnom Penh, Cambodia Inst Pasteur Cambodge, Phnom Penh, Cambodia Inst Pasteur Cambodge Phnom Penh Cambodia ambodge, Phnom Penh, Cambodia
Titolo Testata:
JOURNAL OF CLINICAL INVESTIGATION
fascicolo: 9, volume: 105, anno: 2000,
pagine: 1317 - 1324
SICI:
0021-9738(200005)105:9<1317:ITCSIR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
VERSUS-HOST DISEASE; MYCOBACTERIUM-TUBERCULOSIS; INTERFERON-GAMMA; IN-VIVO; INFECTED MICE; IFN-GAMMA; ANTIGEN; INDUCTION; RECEPTOR; IL-10;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Boussiotis, VA Dana Farber Canc Inst, Dept Adult Oncol, Smith 852,44 Binney St, Boston, MA 02115 USA Dana Farber Canc Inst Smith 852,44 Binney St Boston MA USA 02115
Citazione:
V.A. Boussiotis et al., "IL-10-producing T cells suppress immune responses in anergic tuberculosis patients", J CLIN INV, 105(9), 2000, pp. 1317-1324

Abstract

The lethality of Mycobacterium tuberculosis remains the highest among infectious organisms and is linked to inadequate immune response of the host. Containment and cure of tuberculosis requires an effective cell-mediated immune response, and the absence, during active tuberculosis infection, of delayed-type hypersensitivity (DTH) responses to mycobacterial antigens, defined as anergy, is associated with poor clinical outcome. To investigate the biochemical events associated with this anergy, we screened 206 patients with pulmonary tuberculosis and identified anergic patients by their lack of dermal reactivity to tuberculin purified protein derivative (PPD). In vitrostimulation of T cells with PPD induced production of IL-10, IFN-gamma, and proliferation in PPD+ patients, whereas cells from anergic patients produced IL-10 but not IFN-gamma and failed to proliferate in response to this treatment. Moreover, in anergic patients IL-10-producing T cells were constitutively present, and T-cell receptor-mediated (TCR-mediated) stimulation resulted in defective phosphorylation of TCR zeta and defective activation of ZAP-70 and MAPK. These results show that T-cell anergy can be induced by antigen in vivo in the intact human host and provide new insights into mechanisms by which M, tuberculosis escapes immune surveillance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:24:37