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Titolo:
Involvement of intracellular calcium stores during oxygen/glucose deprivation in striatal large aspiny interneurons
Autore:
Pisani, A; Bonsi, P; Centonze, D; Giacomini, P; Calabresi, P;
Indirizzi:
Univ Roma Tor Vergata, Dipartimento Neurosci, Neurol Clin, I-00133 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00133 eurol Clin, I-00133 Rome, Italy Osped S Lucia, IRCCS, Rome, Italy Osped S Lucia Rome ItalyOsped S Lucia, IRCCS, Rome, Italy Univ Rome La Sapienza, Neurol Clin, Rome, Italy Univ Rome La Sapienza Rome Italy La Sapienza, Neurol Clin, Rome, Italy
Titolo Testata:
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
fascicolo: 5, volume: 20, anno: 2000,
pagine: 839 - 846
SICI:
0271-678X(200005)20:5<839:IOICSD>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BULLFROG SYMPATHETIC NEURONS; TRANSIENT CEREBRAL-ISCHEMIA; RAT HIPPOCAMPAL-NEURONS; IN-VITRO; CA2+ INFLUX; HUNTINGTONS-DISEASE; BASAL GANGLIA; RELEASE; NEOSTRIATUM; ENERGY;
Keywords:
calcium; electrophysiology; ischemia; sarcoendoplasmic reticulum calcium ATPase pumps; striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Pisani, A Univ Roma Tor Vergata, Dipartimento Neurosci, Neurol Clin, Via Tor Vergata135, I-00133 Rome, Italy Univ Roma Tor Vergata Via Tor Vergata 135 Rome Italy I-00133 ly
Citazione:
A. Pisani et al., "Involvement of intracellular calcium stores during oxygen/glucose deprivation in striatal large aspiny interneurons", J CEREBR B, 20(5), 2000, pp. 839-846

Abstract

Striatal large aspiny interneurons were recorded from a slice preparation using a combined electrophysiologic and microfluorometric approach. The role of intracellular Ca2+ stores was analyzed during combined oxygen/glucose deprivation (OGD). Before addressing the role of the stores during energy deprivation, the authors investigated their function under physiologic conditions. Trains of depolarizing current pulses caused bursts of action potentials coupled to transient increases in intracellular calcium concentration ([Ca2+](i)). In the presence of cyclopiazonic acid (30 mu mol/L), a selective inhibitor of the sarcoendoplasmic reticulum Ca2+ pumps, or when ryanodine receptors were directly blocked with ryanodine (20 mu mol/L), the [Ca2+](i) transients were progressively smaller in amplitude, suggesting that [Ca2]; released from intracellular stores helps to maintain a critical level of [Ca2+], during physiologic firing activity. As the authors have recently reported, brief exposure to combined OGD induced a membrane hyperpolarization coupled to an increase in [Ca2+](i). In the presence of cyclopiazonic acid or ryanodine, the hyperpolarization and the rise in [Ca2+](i) induced byOGD were consistently reduced. These data support the hypothesis that Ca2release from ryanodine-sensitive Ca2+ pools is involved not only in the potentiation of the Ca2+ signals resulting from cell depolarization, but alsoin the amplification of the [Ca2+], rise and of the concurrent membrane hyperpolarization observed in course of OGD in striatal large aspiny interneurons.

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Documento generato il 08/07/20 alle ore 07:52:03