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Titolo:
Induced hypothermia in experimental pneumococcal meningitis
Autore:
Angstwurm, K; Reuss, S; Freyer, D; Arnold, G; Dirnagl, U; Schumann, RR; Weber, JR;
Indirizzi:
Humboldt Univ, Klinikum Charite, Dept Neurol, D-10098 Berlin, Germany Humboldt Univ Berlin Germany D-10098 ept Neurol, D-10098 Berlin, Germany Humboldt Univ, Klinikum Charite, Inst Microbiol & Hyg, D-10098 Berlin, Germany Humboldt Univ Berlin Germany D-10098 biol & Hyg, D-10098 Berlin, Germany
Titolo Testata:
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
fascicolo: 5, volume: 20, anno: 2000,
pagine: 834 - 838
SICI:
0271-678X(200005)20:5<834:IHIEPM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE BACTERIAL-MENINGITIS; CONTROLLED CORTICAL IMPACT; TRAUMATIC BRAIN INJURY; MODERATE HYPOTHERMIA; CARDIOPULMONARY BYPASS; MILD HYPOTHERMIA; NITRIC-OXIDE; BLOOD-FLOW; RAT; RABBITS;
Keywords:
brain edema; cerebral blood flow; intracranial hypertension; laser Doppler flowmetry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Weber, JR Humboldt Univ, Klinikum Charite, Dept Neurol, Clara Zetkin Str 94, D-10098Berlin, Germany Humboldt Univ Clara Zetkin Str 94 Berlin GermanyD-10098 ermany
Citazione:
K. Angstwurm et al., "Induced hypothermia in experimental pneumococcal meningitis", J CEREBR B, 20(5), 2000, pp. 834-838

Abstract

Pneumococcal meningitis resulting from Streptococcus pneumoniae has a death rate of 28% in adults. In severe bead injury and stroke, inflammatory changes and intracranial hypertension are improved by induced hypothermia, which also is neuroprotective. We hypothesized that moderate hypother- mia ameliorates inflammatory changes in experimental pneumococcal meningitis. Wistar rats were cooled systemically, and meningitis was induced by pneumococcal cell wall components. The increase of regional cerebral blood flow in themeningitis animals was blocked by hypothermia at 6 hours. The reduction ofintracranial pressure correlated with temperature. The influx of leukocytes into the cerebrospinal fluid and levels of tumor necrosis factor alpha inthe cerebrospinal fluid were decreased. Cooling the animals 2 hours after meningitis induction to 30.5 degrees C was also protective. We conclude that hypothermia is a new adjuvant approach to reduce meningitis-induced changes, in particular intracranial pressure, in the early phase of the disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:19:56