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Titolo:
Effects of alpha-2 blockade on sexual response: experimental studies with Delequamine (RS15385)
Autore:
Bancroft, J;
Indirizzi:
Indiana Univ, Kinsey Inst, Bloomington, IN 46164 USA Indiana Univ Bloomington IN USA 46164 sey Inst, Bloomington, IN 46164 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
, volume: 12, anno: 2000, supplemento:, 1
pagine: S64 - S69
SICI:
0955-9930(200003)12:<S64:EOABOS>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NOCTURNAL PENILE TUMESCENCE; HUMAN CORPUS CAVERNOSUM; VISUAL EROTIC STIMULI; ALPHA-2-ADRENOCEPTOR ANTAGONIST; ERECTILE RESPONSE; HYPOGONADAL MEN; YOHIMBINE; TESTOSTERONE; DYSFUNCTION; REPLACEMENT;
Keywords:
alpha-2 blockade; delequamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Bancroft, J Indiana Univ, Kinsey Inst, Morrison Hall 313, Bloomington, IN 46164 USA Indiana Univ Morrison Hall 313 Bloomington IN USA 46164 64 USA
Citazione:
J. Bancroft, "Effects of alpha-2 blockade on sexual response: experimental studies with Delequamine (RS15385)", INT J IMPOT, 12, 2000, pp. S64-S69

Abstract

The role of alpha-2 receptors and alpha-2 antagonists in central and peripheral mechanisms of sexual response are discussed. It is concluded that thepredominant role of the alpha-a antagonist centrally is to increase arousal which in certain circumstances, is sexual. It is further concluded that the predominant role of the alpha-2 antagonist peripherally is to modulate (block) the norepinephrine (NE)-induced contractility in the smooth muscle of the penis. How the central arousal mechanisms are specifically linked to sexual response is not understood. Experimental studies with a selective alpha-2 antagonist, delequamine, arebriefly reviewed and their complex results discussed. Evidence from sleep studies was consistent with delequamine having both central excitatory and inhibitory effects, dependent on dosage, The possibility that men with psychogenic erectile dysfunction might have increased central alpha-2 tone was considered. The apparent loss of responsiveness to the alpha 2 antagonist in older dysfunctional men was discussed. More questions are raised than answered; further research is needed in this area.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 08:19:12