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Titolo:
Cysteine proteinases and their inhibitors in extracellular fluids: Markersfor diagnosis and prognosis in cancer
Autore:
Kos, J; Werle, B; Lah, T; Brunner, N;
Indirizzi:
Univ Ljubljana, Jozef Stefan Inst, Dept Biochem & Mol Biol, SI-1000 Ljubljana, Slovenia Univ Ljubljana Ljubljana Slovenia SI-1000 l, SI-1000 Ljubljana, Slovenia Krka FF, R&D Div, Dept Biochem Res & Drug Design, Ljubljana, Slovenia KrkaFF Ljubljana Slovenia ochem Res & Drug Design, Ljubljana, Slovenia Thorax Hosp Heidelberg, Rohrbach GmbH, Dept Clin Chem & Bacteriol, Heidelberg, Germany Thorax Hosp Heidelberg Heidelberg Germany acteriol, Heidelberg, Germany Natl Inst Biol, Dept Genet Toxicol & Canc Biol, Ljubljana, Slovenia Natl Inst Biol Ljubljana Slovenia icol & Canc Biol, Ljubljana, Slovenia Rigshosp, Finsen Lab, DK-2100 Copenhagen, Denmark Rigshosp Copenhagen Denmark DK-2100 sen Lab, DK-2100 Copenhagen, Denmark
Titolo Testata:
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS
fascicolo: 1, volume: 15, anno: 2000,
pagine: 84 - 89
SICI:
0393-6155(200001/03)15:1<84:CPATII>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM CYSTATIN-C; GLOMERULAR-FILTRATION RATE; B-LIKE ACTIVITY; CATHEPSIN-B; COLORECTAL-CANCER; STEFIN-A; BREAST-CANCER; CARCINOMA; TUMOR; PROGRESSION;
Keywords:
cathepsins; cystatins; stefins; cancer; serum; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Kos, J Univ Ljubljana, Jozef Stefan Inst, Dept Biochem & Mol Biol, Jamova 39, SI-1000 Ljubljana, Slovenia Univ Ljubljana Jamova 39 Ljubljana Slovenia SI-1000 jana, Slovenia
Citazione:
J. Kos et al., "Cysteine proteinases and their inhibitors in extracellular fluids: Markersfor diagnosis and prognosis in cancer", INT J B MAR, 15(1), 2000, pp. 84-89

Abstract

Cathepsins B, H and L have been shown to participate in processes of tumorgrowth, vascularization, invasion and metastasis. Their levels in tumor tissue extracts can provide useful clinical information to predict disease-free and overall survival in breast, lung, colorectal, brain and head and neck cancer patients. Recently we have found that both cystine cathepsins and their endogenous protein inhibitors stefins and cystatin C cart also predict prognosis when measured extracellularly In melanoma and colorectal cancerpatients high serum levels of cathepsins B and H correlated with shorter survival. Similarly, increased extracellular levels of stefins A and B and cystatin C cor-related significantly with high risk of adverse outcome in cancer patients. However, the cathepsin B/cystatin C complex was found to be less abundant in set-a of patients with malignant tumors than in those withbenign diseases or ill healthy controls, suggesting an imbalance between the enzyme and its inhibitor in cancer patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:14:14