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Titolo:
Effect of risperidone on plasma free 3-methoxy-4-hydroxyphenylglycol (pMHPG) levels in schizophrenic patients: relationship among plasma concentrations of risperidone and 9-hydroxyrisperidone, pMHPG levels, and clinical improvement
Autore:
Yoshimura, R; Nakamura, J; Ueda, N; Terao, T;
Indirizzi:
Univ Occupat & Environm Hlth, Sch Med, Dept Psychiat, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 8555, Japan
Titolo Testata:
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 15, anno: 2000,
pagine: 175 - 180
SICI:
0268-1315(200005)15:3<175:EOROPF>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; MEDIAL PREFRONTAL CORTEX; EXTRACELLULAR DOPAMINE; MONOAMINE METABOLITES; CEREBROSPINAL-FLUID; ANTIPSYCHOTIC-DRUGS; HOMOVANILLIC-ACID; CLOZAPINE; BRAIN; NOREPINEPHRINE;
Keywords:
homovanillic acid; 5-hydroxyindoleacetic acid; 9-hydroxyrisperidone; 3-methoxy-4-hydroxyphenylglycol; risperidone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Yoshimura, R Univ Occupat & Environm Hlth, Sch Med, Dept Psychiat, Yahatanishi Ku, 1-1 Iseigaoka, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth 1-1 Iseigaoka Kitakyushu Fukuoka Japan 8078555
Citazione:
R. Yoshimura et al., "Effect of risperidone on plasma free 3-methoxy-4-hydroxyphenylglycol (pMHPG) levels in schizophrenic patients: relationship among plasma concentrations of risperidone and 9-hydroxyrisperidone, pMHPG levels, and clinical improvement", INT CLIN PS, 15(3), 2000, pp. 175-180

Abstract

We examined the relationships among the clinical efficacies of risperidone, plasma concentrations of risperidone and its active metabolite, 9-hydroxyrisperidone, and changes in plasma free MHPG (pMHPG) in 14 schizophrenic patients. Clinical improvement in negative symptoms of schizophrenia treated with risperidone has been associated with increased pMHPG and, in the present study, there were positive correlations between plasma 9-hydroxyrisperidone concentrations and increased pMHPG levels. These results suggest that risperidone might improve negative symptoms in schizophrenia by influencing noradrenergic neurons. (C) 2000 Lippincott Williams Be Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 17:16:52