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Titolo:
Antibodies in human infectious disease
Autore:
Parren, PWHI; Poignard, P; Ditzel, HJ; Williamson, RA; Burton, DR;
Indirizzi:
Scripps Clin & Res Inst, Dept Immunol, La Jolla, CA 92037 USA Scripps Clin& Res Inst La Jolla CA USA 92037 nol, La Jolla, CA 92037 USA
Titolo Testata:
IMMUNOLOGIC RESEARCH
fascicolo: 2-3, volume: 21, anno: 2000,
pagine: 265 - 278
SICI:
0257-277X(2000)21:2-3<265:AIHID>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; HUMAN MONOCLONAL-ANTIBODY; PHAGE DISPLAY LIBRARIES; PBL-SCID MICE; PRION PROTEIN; NEUTRALIZING ANTIBODIES; COMBINATORIAL LIBRARIES; PASSIVE-IMMUNIZATION; HUMORAL IMMUNITY; FAB FRAGMENTS;
Keywords:
infectious disease; pathogenesis; antibody response; vaccines; human immunodeficiency virus type 1; Ebola virus; respiratory syncytial virus; prion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Burton, DR Scripps Clin & Res Inst, Dept Immunol, 10550 N Torrey Pines Rd,La Jolla, CA 92037 USA Scripps Clin & Res Inst 10550 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
P.W.H.I. Parren et al., "Antibodies in human infectious disease", IMMUNOL RES, 21(2-3), 2000, pp. 265-278

Abstract

Investigation of human antibody responses to viral pathogens at the molecular level is revealing novel aspects of the interplay of viruses with the humoral immune system. In viral infection, at least two types of human antibody responses exist: a response to mature envelope on virions that is neutralizing and a response to immature forms of envelope (viral debris) that isnot. Many pathogens have, to varying degrees, evolved envelopes to minimize antibody responses against epitopes exposed on the virion. In this article, we review recent studies on human immunodeficiency virus type 1, Ebola virus, and respiratory syncytial virus. Prion diseases are diseases of protein conformation. We have generated a large panel of antibodies recognizing the cellular prion protein (PrPc), some of which also react with the abnormally folded infectious prion protein (PrPSc). These antibodies are being used to gain insight into both the molecular events leading to the formation of infectious PrP and the physiologic role played by PrP in normal and prion-infected cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 08:01:02