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Titolo:
Anti-cardiolipin antibodies in fetal blood and amniotic fluid derived frompatients with the anti-phospholipid syndrome
Autore:
Cohen, SB; Goldenberg, M; Rabinovici, J; Lidor, AL; Dulitzky, M; Gilburd, B; Shoenfeld, Y; Schiff, E;
Indirizzi:
Tel Aviv Univ, Sackler Fac Med, Chaim Sheba Med Ctr, Dept Obstet & Gynaecol, IL-52621 Tel Hashomer, Israel Tel Aviv Univ Tel Hashomer Israel IL-52621 IL-52621 Tel Hashomer, Israel Tel Aviv Univ, Sackler Fac Med, Chaim Sheba Med Ctr, Autoimmune Dis Res Unit, IL-52621 Tel Hashomer, Israel Tel Aviv Univ Tel Hashomer Israel IL-52621 IL-52621 Tel Hashomer, Israel Tel Aviv Univ, Sackler Fac Med, Chaim Sheba Med Ctr, Dept Med B, IL-52621 Tel Hashomer, Israel Tel Aviv Univ Tel Hashomer Israel IL-52621 IL-52621 Tel Hashomer, Israel
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 5, volume: 15, anno: 2000,
pagine: 1170 - 1172
SICI:
0268-1161(200005)15:5<1170:AAIFBA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIPHOSPHOLIPID ANTIBODIES; HUMAN-PLATELETS; BETA-2-GLYCOPROTEIN-I; AUTOANTIBODIES; ACTIVATION; WOMEN;
Keywords:
amniotic fluid; anticardiolipin antibodies; antiphospholipid syndrome; fetal cord blood;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Cohen, SB Tel Aviv Univ, Sackler Fac Med, Chaim Sheba Med Ctr, Dept Obstet& Gynaecol, IL-52621 Tel Hashomer, Israel Tel Aviv Univ Tel Hashomer Israel IL-52621 el Hashomer, Israel
Citazione:
S.B. Cohen et al., "Anti-cardiolipin antibodies in fetal blood and amniotic fluid derived frompatients with the anti-phospholipid syndrome", HUM REPR, 15(5), 2000, pp. 1170-1172

Abstract

The aim of this study was to investigate whether, in patients with antiphospholipid syndrome, anticardiolipin antibodies pass from mother to offspring sera and amniotic fluid. Eleven patients with antiphospholipid syndrome (study group) and 11 healthy controls, matched by maternal and gestational age (control group) were prospectively examined for the presence of anticardiolipin antibodies in the cord blood during labour, and amniotic fluid during vaginal or Caesarean delivery. Three neonates (27.3%) in the study grouphad anticardiolipin antibodies in the cord blood, while none had them in the control group. Anticardiolipin antibodies were detected in the amniotic fluid in six (54.5%) of the study group pregnancies, compared with none in the control group. No adverse neonatal outcome was noted except for significantly lower (P < 0.0006) mean birth weight in the study group, Anticardiolipin antibodies can pass the placenta and be detected in fetal cord blood and amniotic fluid. This finding might be used in the future for the assessment of pregnancies with antiphospholipid syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 00:16:55