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Titolo:
Linkage analysis of quantitative trait loci: Sib pairs or sibships?
Autore:
Alcais, A; Abel, L;
Indirizzi:
CHU Pitie Salpetriere, INSERM, U Math & Stat Modeling Biol & Med 436, F-75013 Paris, France CHU Pitie Salpetriere Paris France F-75013 ed 436, F-75013 Paris, France
Titolo Testata:
HUMAN HEREDITY
fascicolo: 4, volume: 50, anno: 2000,
pagine: 251 - 256
SICI:
0001-5652(200007/08)50:4<251:LAOQTL>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
POWER; SEGREGATION; SELECTION;
Keywords:
linkage analysis; quantitative trait locus; maximum likelihood binomial; selected sib pair; sibships;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Alcais, A CHU Pitie Salpetriere, INSERM, U Math & Stat Modeling Biol & Med436, 91 Blvd Hop, F-75013 Paris, France CHU Pitie Salpetriere 91 Blvd Hop Paris France F-75013 , France
Citazione:
A. Alcais e L. Abel, "Linkage analysis of quantitative trait loci: Sib pairs or sibships?", HUMAN HERED, 50(4), 2000, pp. 251-256

Abstract

Sib pair linkage studies are now widely used to investigate the genetic factors implicated in complex quantitative traits. To increase the power of these approaches, it has been proposed to select extremely discordant (ED) sib pairs which are expected to contain the highest linkage information. However, it is known that sibships of larger size contain more linkage information than independent sib pairs. In this paper we compare, in terms of power and cost considerations, the ED strategy, which uses information on sib pairs only, to the recently developed 'Maximum Likelihood Binomial' sibship-oriented method performed on the whole sibships from which the ED sib pairshave been extracted. We show that the use of these whole sibships is an efficient alternative to approaches focusing on ED sib pairs only. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/05/20 alle ore 15:39:40