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Titolo:
Fine mapping of quantitative trait loci using linkage disequilibria with closely linked marker loci
Autore:
Meuwissen, THE; Goddard, ME;
Indirizzi:
Res Inst Anim Sci & Hlth, NL-8500 AB Lelystad, Netherlands Res Inst Anim Sci & Hlth Lelystad Netherlands NL-8500 AB ad, Netherlands Univ Melbourne, Inst Land & Food Resources, Parkville, Vic 3052, AustraliaUniv Melbourne Parkville Vic Australia 3052 arkville, Vic 3052, Australia
Titolo Testata:
GENETICS
fascicolo: 1, volume: 155, anno: 2000,
pagine: 421 - 430
SICI:
0016-6731(200005)155:1<421:FMOQTL>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE; POPULATIONS; LOCATION; DISEASE; MAP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Meuwissen, THE DLO, Inst Anim Sci & Hlth, Dept Anim Breeding & Genet, Box 65, NL-8200 AB Lelystad, Netherlands DLO Box 65 Lelystad Netherlands NL-8200 AB ad, Netherlands
Citazione:
T.H.E. Meuwissen e M.E. Goddard, "Fine mapping of quantitative trait loci using linkage disequilibria with closely linked marker loci", GENETICS, 155(1), 2000, pp. 421-430

Abstract

A multimarker linkage disequilibrium mapping method was developed for the fine mapping of quantitative trait loci (QTL) using a dense marker map. Themethod compares the expected covariances between haplotype effects given apostulated QTL position tu the covariances that are found in the data. Theexpected covariances between the haplotype effects are proportional to theprobability that the QTL position is identical by descent (IBD) given the marker haplotype information, which is calculated using the genedropping method. Simulation results showed that a QTL was correctly positioned within a region of 3, 1.5, or 0.75 cM in 70, 62, and 68%, respectively, of the replicates using markers spaced at intervals of 1, 0.5, and 0.25 cM, respectively. These results were rather insensitive to the number of generations since the QTL occurred and to the effective population size, except that 10 generations yielded rather poor estimates of the QTL position. The position estimates of this multimarker disequilibrium mapping method were more accurate than those from a single marker transmission disequilibrium test. A general approach for identifying QTL is suggested, where several stages of disequilibrium mapping are used with increasingly dense marker spacing.

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Documento generato il 22/09/20 alle ore 17:26:39