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Titolo:
Pregnancies and deliveries after in vitro maturation culture followed by in vitro fertilization and embryo transfer without stimulation in women withpolycystic ovary syndrome
Autore:
Cha, KY; Han, SY; Chung, HM; Choi, DH; Lim, JM; Lee, WS; Ko, JJ; Yoon, TK;
Indirizzi:
Pochon CHA Univ, Coll Med, CHA Gen Hosp, Infertil Med Ctr, Seoul 135081, South Korea Pochon CHA Univ Seoul South Korea 135081 Ctr, Seoul 135081, South Korea
Titolo Testata:
FERTILITY AND STERILITY
fascicolo: 5, volume: 73, anno: 2000,
pagine: 978 - 983
SICI:
0015-0282(200005)73:5<978:PADAIV>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACYTOPLASMIC SPERM INJECTION; INVITRO FERTILIZATION; HUMAN OOCYTES; IN-VITRO; LUTEINIZING-HORMONE; IMPLANTATION; COCULTURE; GONADOTROPIN; FIBROBLASTS; CYCLES;
Keywords:
human; immature oocytes; polycystic ovary syndrome (PCOS); in vitro maturation; pregnancy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Chung, HM Pochon CHA Univ, Coll Med, CHA Gen Hosp, Infertil Med Ctr, 606-5Yeoksam 1Dong, Seoul 135081, South Korea Pochon CHA Univ 606-5 Yeoksam 1 Dong Seoul South Korea 135081 a
Citazione:
K.Y. Cha et al., "Pregnancies and deliveries after in vitro maturation culture followed by in vitro fertilization and embryo transfer without stimulation in women withpolycystic ovary syndrome", FERT STERIL, 73(5), 2000, pp. 978-983

Abstract

Objective: To improve the efficacy of an IVF-ET program for unstimulated patients with polycystic ovary syndrome (PCOS) with the se of culture for oocyte maturation. Design: Prospective studies with the comparison of different ET proceduresfrom March 1995 through February 1998. Setting: University-affiliate hospital. Patient(s): Ninety-four cycles in 64 consenting patients with PCOS. Intervention(s): Immature oocytes were retrieved from unstimulated patients with PCOS and subsequently cultured and fertilized in vitro. Zygote intrafallopian transfer (ZIFT), uterine ET, or a combined approach of ZIFT + uterine ET was subsequently performed. Main Outcome Measure(s): Laboratory and clinical data. Result(s): Among 1,280 immature oocytes (13.6 +/- 7.5 oocytes per patient)retrieved, 89% (1,139) were morphologically normal, and 62.2% (708/1,139) of the normal oocytes matured in vitro after culture for 48 hours. When intracytoplasmic sperm injection was performed, 68% (481/708) developed to thenormal pronuclear stage, and 88.1% of the embryos cocultured with Vero cells (266/302) cleaved. Eighty-five ET cycles were conducted and pregnancy was established in 23 cycles (27.1%), which consisted of 8 after uterine ET and 15 after a combined approach. Seventeen patients delivered 20 normal infants. Conclusion(s): The IVF-ET method using no ovarian stimulation followed by in vitro maturation culture can be a feasible assisted reproductive technology for treatment of PCOS with various complications. (Fertil Steril(R) 2000;73:978-83. (C) 2000 by American Society for Reproductive Medicine).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 03:23:23