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Titolo:
Heat induced expression of CD95 and its correlation with the activation ofapoptosis upon heat shock in rat histiocytic tumor cells
Autore:
Sreedhar, AS; Pardhasaradhi, BVV; Khar, A; Srinivas, UK;
Indirizzi:
Ctr Cellular & Mol Biol, Hyderabad 500007, Andhra Pradesh, India Ctr Cellular & Mol Biol Hyderabad Andhra Pradesh India 500007 desh, India
Titolo Testata:
FEBS LETTERS
fascicolo: 2-3, volume: 472, anno: 2000,
pagine: 271 - 275
SICI:
0014-5793(20000428)472:2-3<271:HIEOCA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELL; DEATH FACTOR; INDUCTION; PROTEINS; RESISTANCE; PROTEASES; EXECUTION; LIGAND; STRESS;
Keywords:
CD95; heat shock protein; heat shock factor; apoptosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Srinivas, UK Ctr Cellular & Mol Biol, Uppal Rd, Hyderabad 500007, Andhra Pradesh, India Ctr Cellular & Mol Biol Uppal Rd Hyderabad Andhra Pradesh India 500007
Citazione:
A.S. Sreedhar et al., "Heat induced expression of CD95 and its correlation with the activation ofapoptosis upon heat shock in rat histiocytic tumor cells", FEBS LETTER, 472(2-3), 2000, pp. 271-275

Abstract

The heat shock response is a universal phenomenon and is among the most highly conserved cellular responses. However, BC-8, a rat histiocytoma, failsto mount a heat shock response unlike all other eukaryotic cells. In the absence of induction of heat shock proteins, apoptotic cell death is activated in BC-8 tumor cells: upon heat shock, We demonstrate here that stable transformants of BC-8 tumor cells transfected with hsp70 cDNA constitutively express hsp70 protein and are transiently protected from heat induced apoptosis for 6-8 h. In addition heat stress induces CD95 gene expression in these tumor cells, There is a delay in CD95 expression in hsp70 transfected cells suggesting a correlation between the cell surface expression of CD95 and the time of induction of apoptosis in this tumor cell line, Also expression of CD95 antigen appears to inhibit the interaction between heat shock factors and heat shock elements in these cells resulting in the lack of heat shock response. (C) 2000 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 16:58:10