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Titolo:
Identification of residues in the TPR domain of Ssn6 responsible for interaction with the Tup1 protein
Autore:
Gounalaki, N; Tzamarias, D; Vlassi, M;
Indirizzi:
Natl Ctr Sci Res Demokritos, Inst Biol, Athens 15310, Greece Natl Ctr Sci Res Demokritos Athens Greece 15310 ol, Athens 15310, Greece Inst Mol Biol & Biotechnol, Fdn Res & Technol, Heraklion, Crete, Greece Inst Mol Biol & Biotechnol Heraklion Crete Greece raklion, Crete, Greece
Titolo Testata:
FEBS LETTERS
fascicolo: 1, volume: 473, anno: 2000,
pagine: 37 - 41
SICI:
0014-5793(20000504)473:1<37:IORITT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTIONAL CO-REPRESSOR; TETRATRICOPEPTIDE REPEAT PROTEIN; COREPRESSOR COMPLEX; NADPH OXIDASE; FAMILY; YEAST; ENHANCER; POSITION; PROGRAM; MOTIFS;
Keywords:
tetratricopeptide repeat motif; transcription; protein-protein interaction; Ssn6; Tup1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Vlassi, M Natl Ctr Sci Res Demokritos, Inst Biol, POB 60228, Athens 15310,Greece Natl Ctr Sci Res Demokritos POB 60228 Athens Greece 15310 reece
Citazione:
N. Gounalaki et al., "Identification of residues in the TPR domain of Ssn6 responsible for interaction with the Tup1 protein", FEBS LETTER, 473(1), 2000, pp. 37-41

Abstract

Ssn6, a yeast protein that comprises 10 tandem tetratricopeptide repeat (TPR) motifs, associates with Tup1 repressor protein and acts as a transcriptional corepressor, In this report we identify point mutations in the TPR1 of Ssn6 that disrupt Tup1 interaction. Furthermore, we construct a 3D model of the TPR domain of Ssn6 which is responsible for Tup1 binding, based on the known structure of protein phosphatase 5. According to this model all selected mutations reduce the ability of Ssn6 to interact with Tup1 by affecting: the structural integrity of TPR1 and/or the correct spatial arrangement of TPR1 relative to TPR2 and TPR3, (C) 2000 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:02:18