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Titolo:
Effects of vasopressin and epinephrine on splanchnic blood flow and renal function during and after cardiopulmonary resuscitation in pigs
Autore:
Voelckel, WG; Lindner, KH; Wenzel, V; Bonatti, J; Hangler, H; Frimmel, C; Kunszberg, E; Lingnau, W;
Indirizzi:
Innsbruck Univ, Dept Anaesthesia & Intens Care Med, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 e Med, A-6020 Innsbruck, Austria Innsbruck Univ, Dept Surg, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 Surg, A-6020 Innsbruck, Austria
Titolo Testata:
CRITICAL CARE MEDICINE
fascicolo: 4, volume: 28, anno: 2000,
pagine: 1083 - 1088
SICI:
0090-3493(200004)28:4<1083:EOVAEO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFUSION-PRESSURE; CARDIOGENIC-SHOCK; CARDIAC-ARREST; RAT; MECHANISM; CHEST;
Keywords:
blood flow; cardiac arrest; cardiopulmonary resuscitation; vasopressin; epinephrine; return of spontaneous circulation; ultrasound flow probes; splanchnic perfusion; renal function; postresuscitation phase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Voelckel, WG Innsbruck Univ, Dept Anaesthesia & Intens Care Med, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 Innsbruck, Austria
Citazione:
W.G. Voelckel et al., "Effects of vasopressin and epinephrine on splanchnic blood flow and renal function during and after cardiopulmonary resuscitation in pigs", CRIT CARE M, 28(4), 2000, pp. 1083-1088

Abstract

Objective: To compare the effects of vasopressin versus epinephrine on splanchnic blood flow during and after cardiopulmonary resuscitation (CPR), and to evaluate the effects of these vasopressors on renal function in the postresuscitation phase,Design: Prospective, randomized laboratory investigation using an established porcine CPR model with instrumentation for continuous measurement of splanchnic and renal blood flow. Setting: University hospital experimental laboratory,Subjects: A total of 12 anesthetized, 12- to 16-wk-old domestic pigs weighing 30-35 kg,Interventions: After 4 mins of cardiac arrest, and 3 mins of CPR, 12 pigs were randomly assigned to receive either 0.4 units/kg vasopressin (n = 6) or 45 mu g/kg epinephrine (n = 6), Defibrillation was performed 5 mins afterdrug administration; all animals were observed for 6 hrs after return of spontaneous circulation (ROSC),Measurements and Main Results: Mean +/- SEM superior mesenteric artery blood flow was significantly (p < .05) lower after vasopressin compared with epinephrine at 90 sees after drug administration (13 +/- 3 vs, 129 +/- 33 mL/min); at 5 mins after drug administration (31 +/- 18 vs. 155 +/- 39 mL/min); at 5 mins after ROSC (332 +/- 47 vs. 1087 +/- 166 mL/min); and at 15 mins after ROSC (450 +/- 106 vs. 1130 +/- 222 mL/min); respectively. Mean +/- SEM left renal and hepatic artery blood flow after ROSC was comparable in both groups ranging between 120-290 mL/min (renal blood flow), and 150-360 mL/min (hepatic blood flow), respectively. Median urine output after ROSC showed no difference between groups, and highest values (180-220 mL/hr) were observed in the first 60 mins after ROSC, Median calculated glomerular filtration rate showed no difference between groups with values ranging between30 and 80 mL/min in the postresuscitation phase. Calculated fractional sodium excretion and osmolar relationship between urea and plasma indicated noevidence for renal tubular dysfunction,Conclusions: In the early postresuscitation phase, superior mesenteric blood flow was temporarily impaired by vasopressin in comparison with epinephrine. With respect to renal blood flow and renal function after ROSC, there was no difference between either vasopressor given during CPR, Vasopressin given during CPR did not result in an antidiuretic state in the postresuscitation phase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:23:20