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Titolo:
Coexpression of MUC1 glycoprotein with multiple angiogenic factors in non-small cell lung cancer suggests coactivation of angiogenic and migration pathways
Autore:
Giatromanolaki, A; Koukourakis, MI; Sivridis, E; OByrne, K; Cox, G; Thorpe, PE; Gatter, KC; Harris, AL;
Indirizzi:
Democritus Univ Thrace, Dept Pathol, Alexandroupolis 68100, Greece Democritus Univ Thrace Alexandroupolis Greece 68100 upolis 68100, Greece Univ Thessalia, Dept Radiotherapy Oncol, Sch Med, Larisa, Greece Univ Thessalia Larisa Greece adiotherapy Oncol, Sch Med, Larisa, Greece Leicester Royal Infirm, Dept Oncol, Leicester LE1 5WW, Leics, England Leicester Royal Infirm Leicester Leics England LE1 5WW WW, Leics, England Univ Texas, SW Med Ctr, Dept Pharmacol, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 Ctr, Dept Pharmacol, Dallas, TX 75235 USA Oxford Radcliffe Hosp, Dept Cellular Sci, Oxford OX3 7LJ, England Oxford Radcliffe Hosp Oxford England OX3 7LJ ci, Oxford OX3 7LJ, England Oxford Radcliffe Hosp, Imperial Canc Res Fund, Med Oncol Unit, Oxford OX3 7LJ, England Oxford Radcliffe Hosp Oxford England OX3 7LJ it, Oxford OX3 7LJ, England
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 5, volume: 6, anno: 2000,
pagine: 1917 - 1921
SICI:
1078-0432(200005)6:5<1917:COMGWM>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY COMPLEX; ENDOTHELIAL GROWTH-FACTOR; BREAST-CANCER; EPISIALIN MUC1; EXPRESSION; ADHESION; ADENOCARCINOMA; CARCINOMAS; PROGNOSIS; SURVIVAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Koukourakis, MI Tumour & Angiogenesis Res Grp, 18 Dimokratias Ave, Iraklion 71306, Crete, Greece Tumour & Angiogenesis Res Grp 18 Dimokratias Ave Iraklion Crete Greece 71306
Citazione:
A. Giatromanolaki et al., "Coexpression of MUC1 glycoprotein with multiple angiogenic factors in non-small cell lung cancer suggests coactivation of angiogenic and migration pathways", CLIN CANC R, 6(5), 2000, pp. 1917-1921

Abstract

We investigated the expression of MUC1 protein and its relationship to themicrovessel density and the expression of thymidine phosphorylase, vascular endothelial growth factor (VEGF), VEGF-receptor KDR, basic fibroblast growth factor (bFGF), and bFGF-receptor (FGFR-2) in non-small cell lung cancer, Although MUC1 expression was found equally in poorly and highly vascularized tumors, a significant coexpression with multiple angiogenic factors andtheir receptors was noted (P = 0.0002, 0.03, 0.19, 0.10, and 0.01 for thymidine phosphorylase, VEGF, KDR, bFGF, and FGFR-2, respectively). In multiple regression analysis, both angiogenesis and MUC1 expression were independent prognostic variables. The present study suggests the existence of an early genetic event leading to the activation of both migration and angiogenesis pathways in non-small cell lung cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 03:49:09