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Titolo:
Gadolinium decreases stretch-induced vulnerability to atrial fibrillation
Autore:
Bode, F; Katchman, A; Woosley, RL; Franz, MR;
Indirizzi:
Georgetown Univ, Dept Pharmacol, Washington, DC USA Georgetown Univ Washington DC USA iv, Dept Pharmacol, Washington, DC USA Vet Affairs Med Ctr, Div Cardiol, Washington, DC 20422 USA Vet Affairs MedCtr Washington DC USA 20422 iol, Washington, DC 20422 USA
Titolo Testata:
CIRCULATION
fascicolo: 18, volume: 101, anno: 2000,
pagine: 2200 - 2205
SICI:
0009-7322(20000509)101:18<2200:GDSVTA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTRACTION-EXCITATION FEEDBACK; ISOLATED VENTRICULAR MYOCYTES; ACTIVATED ION CHANNELS; CULTURED CHICK HEART; INDUCED ARRHYTHMIAS; REFRACTORY PERIOD; GUINEA-PIG; RAT-HEART; HUMANS; TEMPERATURE;
Keywords:
stretch; channels; fibrillation; gadolinium; mechanics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Franz, MR Vet Adm Med Ctr, Div Cardiol, 50 Irving St NW, Washington, DC 20422 USA Vet Adm Med Ctr 50 Irving St NW Washington DC USA 20422 0422 USA
Citazione:
F. Bode et al., "Gadolinium decreases stretch-induced vulnerability to atrial fibrillation", CIRCULATION, 101(18), 2000, pp. 2200-2205

Abstract

Background-Atrial fibrillation (AF) is frequently associated with atrial dilatation caused by pressure or volume overload. Stretch-activated channels(SACs) have been found in myocardial cells and may promote AI: in dilated atl ia. To prove this hypothesis, we investigated the effect of the SAC blocker gadolinium (Gd3+) on AF propensity in the isolated rabbit heart duringatrial stretch. Methods and Results-In 16 isolated Langendorff-perfused rabbit hearts, theinteratrial septum was perforated to equalize biatrial pressures. Caval and pulmonary veins were occluded. Intra-atrial pressure (IAP) was increased in steps of ? to 3 cm H2O by increasing the pulmonary outflow fluid column. Vulnerability to AF was evaluated by 15-second burst pacing at each IAP level, At baseline, IAP needed to be raised to 8.8+/-0.2 cm H2O (mean+/-SEM) to induce AF, A dose-dependent decrease in AF vulnerability was observed after Gd3+ 12.5, 25, and 50 mu mol/L was added, AF threshold increased to 19.0+/-0.5 cm H2O with Gd3+ 50 mu mol/L (P<0.001 versus baseline). Spontaneousruns of AF occurred in 5 hearts on a rise of IAP to 13.8+/-3.3 cm H2O at baseline but never during Gd3+. Atrial effective refractory period shortenedprogressively from 78+/-3 ms at 0.5 cm H2O to 52+/-3 ms at 20 cm H2O (P<0.05). Gd3+ 50 mu mol/L had no significant effect on effective refractory period. Conclusions-Acute atrial stretch significantly enhances the vulnerability to AF, Gd3+ reduces the stretch-induced vulnerability to AF in a dose-dependent manner. Block of SAC might represent a novel antiarrhythmic approach to AF under conditions of elevated atrial pressure or volume.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:00:32