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Titolo:
Neural stem cells: From cell biology to cell replacement
Autore:
Armstrong, RJE; Svendsen, CN;
Indirizzi:
Univ Cambridge, Ctr Brain Repair, Cambridge CB2 2PY, England Univ Cambridge Cambridge England CB2 2PY air, Cambridge CB2 2PY, England
Titolo Testata:
CELL TRANSPLANTATION
fascicolo: 2, volume: 9, anno: 2000,
pagine: 139 - 152
SICI:
0963-6897(200003/04)9:2<139:NSCFCB>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; FIBROBLAST GROWTH-FACTOR; ADULT-RAT BRAIN; GLIAL-RESTRICTED PRECURSORS; IN-VITRO PROPAGATION; LONG-TERM SURVIVAL; HUMAN FETAL BRAIN; PROGENITOR CELLS; NEURONAL PRECURSORS; MAMMALIAN FOREBRAIN;
Keywords:
stem cell; neural transplantation; EGF; FGF-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
121
Recensione:
Indirizzi per estratti:
Indirizzo: Armstrong, RJE Univ Cambridge, Ctr Brain Repair, Forvie Site,Robinson Way,Cambridge CB2 2PY, England Univ Cambridge Forvie Site,Robinson Way Cambridge England CB2 2PY
Citazione:
R.J.E. Armstrong e C.N. Svendsen, "Neural stem cells: From cell biology to cell replacement", CELL TRANSP, 9(2), 2000, pp. 139-152

Abstract

A large number of crippling neurological conditions result from the loss of certain cell populations from the nervous system through disease or injury, and these cells are not intrinsically replaced. Mounting evidence now suggests that replacement of depleted cell populations by transplantation maybe of functional benefit in many such diseases. A diverse range of cell populations is vulnerable, and the loss of specific populations results in circumscribed deficits in different conditions. This diversity presents a considerable challenge if cell replacement therapy is to become widely applicable in the clinical domain, because each condition has specific requirements for the phenotype. developmental stage, and number of cells required. An ideal cell for universal application in cell replacement therapy would possess several key properties: it would be highly proliferative, allowing the ex vivo production of large numbers of cells from minimal donor material, it would also remain immature and phenotypically plastic such that it could differentiate into appropriate neural and glial cell types on, or prior to,transplantation. Critically, both proliferation and differentiation would be controllable. This review considers some of the evidence that stem cellsexist in the central nervous system and that they may possess characteristics that make them ideal for broad application in cell replacement therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 00:33:51