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Titolo:
Cellular and humoral immune responses to adenovirus and p53 protein antigens in patients following intratumoral injection of an adenovirus vector expressing wild-type p53 (Ad-p53)
Autore:
Yen, N; Ioannides, CG; Xu, K; Swisher, SG; Lawrence, DD; Kemp, BL; El-Naggar, AK; Cristiano, RJ; Fang, BL; Glisson, BS; Hong, WK; Khuri, FR; Kurie, JM; Lee, JJ; Lee, JS; Merritt, JA; Mukhopadhyay, T; Nesbitt, JC; Nguyen, D; Perez-Soler, R; Pisters, KMW; Putnam, JB; Schrump, DS; Shin, DM; Walsh, GL; Roth, JA;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Dept Thorac & Cardiovasc Surg, Sect Thorac Mol Oncol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 t Thorac Mol Oncol, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 Dept Gynecol Oncol, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Diagnost Imaging, Houston, TX 77030USA Univ Texas Houston TX USA 77030 pt Diagnost Imaging, Houston, TX 77030USA Univ Texas, MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 c Ctr, Dept Pathol, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 d & Neck Med Oncol, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Biomath, Houston, TX 77030 USA UnivTexas Houston TX USA 77030 Ctr, Dept Biomath, Houston, TX 77030 USA Introgen Therapeut, Houston, TX 77054 USA Introgen Therapeut Houston TX USA 77054 Therapeut, Houston, TX 77054 USA
Titolo Testata:
CANCER GENE THERAPY
fascicolo: 4, volume: 7, anno: 2000,
pagine: 530 - 536
SICI:
0929-1903(200004)7:4<530:CAHIRT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIATED GENE-TRANSFER; PHASE-I TRIAL; LUNG-CANCER; RECOMBINANT ADENOVIRUS; CYSTIC-FIBROSIS; BREAST-CANCER; THERAPY; HEAD; SUPPRESSION; COMBINATION;
Keywords:
adenovirus vector; p53; lung cancer; lymphocyte proliferation; anti-p53 antibodies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Roth, JA Univ Texas, MD Anderson Canc Ctr, Dept Thorac & Cardiovasc Surg, Sect Thorac Mol Oncol, 1515 Holcombe Blvd, Houston, TX 77030 USA Univ Texas1515 Holcombe Blvd Houston TX USA 77030 , TX 77030 USA
Citazione:
N. Yen et al., "Cellular and humoral immune responses to adenovirus and p53 protein antigens in patients following intratumoral injection of an adenovirus vector expressing wild-type p53 (Ad-p53)", CANC GENE T, 7(4), 2000, pp. 530-536

Abstract

The immune responses of 10 patients with advanced non-small cell lung cancer receiving monthly intratumoral injections of a recombinant adenovirus containing human wild-type p53 (Ad-p53) to adenovirus and transgene antigens were studied. The predominate cellular and humoral immune responses as measured by lymphocyte proliferation and neutralizing antibody (Ab) formation were to adenovirus serotype 5 vector antigens, with increased responses in posttreatment samples. Consistent alterations in posttreatment cellular and humoral immune responses to p53 epitopes were not observed, and cytotoxic Abs to human lung cancer cells were not generated. Patients in this study had evidence of an antitumoral effect of this treatment with prolonged tumor stability or regression; however, neither Abs to p53 protein nor increased lymphocyte proliferative responses to wild-type or mutant p53 peptides havebeen consistently detected.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:30:39