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Titolo:
Serum dehydroepiandrosterone and dehydroepiandrosterone sulfate and the subsequent risk of developing colon cancer
Autore:
Alberg, AJ; Gordon, GB; Hoffman, SC; Comstock, GW; Helzlsouer, KJ;
Indirizzi:
Johns Hopkins Sch Hyg & Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USAJohns Hopkins Sch Hyg & Publ Hlth Baltimore MD USA 21205 re, MD 21205 USA Johns Hopkins Oncol Ctr, Bethesda, MD 21205 USA Johns Hopkins Oncol Ctr Bethesda MD USA 21205 Ctr, Bethesda, MD 21205 USA
Titolo Testata:
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
fascicolo: 5, volume: 9, anno: 2000,
pagine: 517 - 521
SICI:
1055-9965(200005)9:5<517:SDADSA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTMENOPAUSAL WOMEN; DEHYDROISOANDROSTERONE SULFATE; SEX-DIFFERENCES; AGE; MEN; TUMORIGENESIS; ANDROGENS; SMOKING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Alberg, AJ Johns Hopkins Sch Hyg & Publ Hlth, Dept Epidemiol, 615 N Wolfe St, Baltimore, MD 21205 USA Johns Hopkins Sch Hyg & Publ Hlth 615 N Wolfe St Baltimore MD USA 21205
Citazione:
A.J. Alberg et al., "Serum dehydroepiandrosterone and dehydroepiandrosterone sulfate and the subsequent risk of developing colon cancer", CANC EPID B, 9(5), 2000, pp. 517-521

Abstract

This purpose of this study was to evaluate whether serum dehydroepiandrosterone (DHEA) and its sulfate conjugate, dehydroepiandrosterone sulfate (DHEAS), are associated with the likelihood of developing colon cancer. A nested case-control study was conducted using the serum bank and cancer registryin Washington County, Maryland. From a population of 20,305 county residents who donated blood in 1974, incident cases of colon cancer that occurred from 1975 to 1991 (n = 117) were matched to one cancer-free control by age,race, and sex. Serum specimens that were stored at -70 degrees C since 1974 were assayed for DHEA and DHEAS. Compared with the controls, the mean serum concentrations of cases were 3% lower for DHEA (P = 0.90) and 13% lower for DHEAS (P = 0.60), When DHEA levels were analyzed according to fourths, no noteworthy associations were observed. Compared with the lowest fourth, the highest fourth of serum DHEAS was nonsignificantly associated with a halving in the risk of colon cancer (odds ratio, 0.50; 95% confidence limits,0.18, 1.37; P-trend = 0.22), and further analyses showed the potential protective association was confined largely to males (highest-versus-lowest fourth odds ratio, 0.26; 95% confidence limits, 0.06, 1.16; P-trend = 0.06). This prospective study does not provide strong evidence that circulating DHEA and DHEAS concentrations are associated with the risk of colon cancer. Among men, DHEAS was associated with a decreased risk of colon cancer, but the association was within the bounds of chance. Further studies are needed to either support or refute the potentially promising lead hinted at by theresults for DHEAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 12:51:16